Sugi Predict

Sugi Predict / Compounds / SCHEMBL257480

SCHEMBL257480

SCHEMBL257480

CCOC(=O)CNS(=O)(=O)c1ccc(C)cc1

nearest known ligand 0.76

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 9/20 0.67
▸ L3MBTL1 Q9Y468 1/20 0.60
▸ GAA P10253 2/20 0.57
▸ KMT2A Q03164 1/20 0.57
▸ SMN1; SMN2 Q16637 4/20 0.56
▸ KDM4E B2RXH2 1/20 0.56
▸ NPC1 O15118 1/20 0.56
▸ HPGD P15428 1/20 0.56
▸ RAB9A P51151 1/20 0.56
▸ PKM P14618 1/20 0.55
▸ LMNA P02545 2/20 0.54
▸ RECQL P46063 1/20 0.54
▸ HSD17B10 Q99714 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13917758 0.95 ALDH1A1 (0.62) ALDH1A1L3MBTL1GAAKMT2ASMN1; SMN2
SCHEMBL7261912 0.88 ALDH1A1 (0.64) ALDH1A1L3MBTL1GAAKMT2ASMN1; SMN2
SCHEMBL6506619 0.88 ALDH1A1 (0.64) ALDH1A1L3MBTL1GAAKMT2ASMN1; SMN2
SCHEMBL25305775 0.87 L3MBTL1 (0.60) ALDH1A1L3MBTL1GAAKMT2ASMN1; SMN2
SCHEMBL570839 0.87 ALDH1A1 (0.73) ALDH1A1L3MBTL1GAAKMT2ASMN1; SMN2
SCHEMBL7345656 0.86 ALDH1A1 (0.62) ALDH1A1L3MBTL1GAASMN1; SMN2KDM4E
SCHEMBL28849841 0.86 ALDH1A1 (0.62) ALDH1A1L3MBTL1GAAKMT2ASMN1; SMN2
SCHEMBL20743530 0.84 ALDH1A1 (0.60) ALDH1A1L3MBTL1GAASMN1; SMN2KDM4E
SCHEMBL22492367 0.84 ALDH1A1 (0.60) ALDH1A1GAAKMT2ASMN1; SMN2KDM4E
SCHEMBL8285177 0.84 MEP1B (0.62) ALDH1A1GAAKMT2ASMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3835300-B1 1,7-NAPHTHYRIDINE DERIVATIVE AND PREPARATION METHOD AND USE THEREFOR CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD (CN) 2025-02-19 — — EP disclosed
US-11981669-B2 1,7-naphthyridine derivative and preparation method and use therefor CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD (CN) 2024-05-14 — — US disclosed
CN-116874395-A Visible light-promoted amino acid alpha-position alkylation modification method 华中科技大学 2023-10-13 — — CN disclosed
CN-112689635-B 1, 7-naphthyridine derivative and preparation method and application thereof 石药集团中奇制药技术（石家庄）有限公司 2023-08-04 — — CN disclosed
CN-111116446-B Synthetic process method of 3-substituted-1H-pyrrole 成都师范学院 2023-07-14 — — CN disclosed
CN-113710669-A Fused bicyclic heterocyclic derivatives as pesticides 拜耳公司 2021-11-26 — — CN disclosed
US-20210332043-A1 1,7-NAPHTHYRIDINE DERIVATIVE AND PREPARATION METHOD AND USE THEREFOR CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD (CN) 2021-10-28 — — US disclosed
EP-3835300-A1 1,7-NAPHTHYRIDINE DERIVATIVE AND PREPARATION METHOD AND USE THEREFOR CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) 2021-06-16 — — EP disclosed
CN-112689635-A 1, 7-naphthyridine derivative and preparation method and application thereof 石药集团中奇制药技术（石家庄）有限公司 2021-04-20 — — CN disclosed
CN-111116446-A Synthetic process method of 3-substituted-1H-pyrrole 成都师范学院 2020-05-08 — — CN disclosed
US-20050143443-A1 Pyrrole and pyrazole DAAO inhibitors SEPRACOR INC. (US) 2005-06-30 — — US disclosed
US-20040180910-A1 Heterocycle carboxamides as antiviral agents SCHNUTE MARK E (US) 2004-09-16 — — US disclosed
US-6730682-B2 HERPES VIRUS PHARMACIA & UPJOHN COMPANY 2004-05-04 — — US disclosed
EP-1363907-A2 HETEROCYCLE CARBOXAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2003-11-26 — — EP disclosed
US-20020019397-A1 Heterocycle carboxamides as antiviral agents PHARMACIA & UPJOHN COMPANY 2002-02-14 — — US disclosed
WO-2002004443-A2 HETEROCYCLE CARBOXAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2002-01-17 — — WO disclosed
CN-1044237-C 4,1-benzoxazep in derivatives and their use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1999-07-21 — — CN disclosed
CN-1083481-A 4,1-Benzoxazepine derivatives and its purposes TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1994-03-09 — — CN disclosed
US-4421693-A INSECTICIDES, MITICIDES OR NEMATOCIDES OTSUKA CHEMICAL CO., LTD. (JP) 1983-12-20 — — US disclosed
US-4413005-A 2,3-DIHYDRO-2,2-DIMETHYLBENZOFURAN-7-YL DERIVATIVES OTSUKA KAGAKU YAKUHIN KABUSHIKI KAISHA (JP) 1983-11-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210332043-A1 1,7-NAPHTHYRIDINE DERIVATIVE AND PREPARATION METHOD AND USE THEREFOR HIF1A, HIF1AN, P4HA1 ALDH1A1 922/4885L3MBTL1 4602/4885GAA 1081/4885
US-20050143443-A1 Pyrrole and pyrazole DAAO inhibitors DDO, DAO, SRR ALDH1A1 3634/4885L3MBTL1 398/4885GAA 2344/4885
US-20040180910-A1 Heterocycle carboxamides as antiviral agents ZC3HAV1, ZC3HAV1L, HDAC1 ALDH1A1 779/4885L3MBTL1 4225/4885GAA 1182/4885
US-20020019397-A1 Heterocycle carboxamides as antiviral agents ZC3HAV1, ZC3HAV1L, HDAC1 ALDH1A1 779/4885L3MBTL1 4225/4885GAA 1182/4885
US-11981669-B2 1,7-naphthyridine derivative and preparation method and use therefor HIF1A, HIF1AN, P4HA1 ALDH1A1 922/4885L3MBTL1 4602/4885GAA 1081/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.