SCHEMBL3239227

SCHEMBL3239227

COC(=O)CNS(=O)(=O)c1ccccc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.71
GAA P10253 3/20 0.71
SMN1; SMN2 Q16637 3/20 0.71
KDM4E B2RXH2 2/20 0.71
NPC1 O15118 1/20 0.71
HPGD P15428 1/20 0.71
RAB9A P51151 1/20 0.71
MMP1 P03956 3/20 0.56
MMP12 P39900 2/20 0.56
PKM P14618 2/20 0.56
MAPK1 P28482 1/20 0.54
MMP2 P08253 2/20 0.51
MMP13 P45452 2/20 0.51
MMP14 P50281 2/20 0.51
MEP1B Q16820 2/20 0.51
MMP3 P08254 1/20 0.51
MMP7 P09237 1/20 0.51
MMP9 P14780 1/20 0.51
MMP8 P22894 1/20 0.51
ADAM17 P78536 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7366406 0.88 ALDH1A1 (0.56) ALDH1A1GAASMN1; SMN2KDM4ENPC1
SCHEMBL570839 0.84 ALDH1A1 (0.73) ALDH1A1GAASMN1; SMN2KDM4ENPC1
SCHEMBL28588397 0.83 ALDH1A1 (0.51) ALDH1A1GAASMN1; SMN2KDM4ENPC1
SCHEMBL24762900 0.83 ALDH1A1 (0.71) ALDH1A1GAASMN1; SMN2KDM4ENPC1
SCHEMBL24762008 0.83 ALDH1A1 (0.71) ALDH1A1GAASMN1; SMN2KDM4ENPC1
SCHEMBL28677877 0.83 KDM4E (0.71) ALDH1A1GAASMN1; SMN2KDM4ENPC1
SCHEMBL24762895 0.83 ALDH1A1 (0.71) ALDH1A1GAASMN1; SMN2KDM4ENPC1
SCHEMBL9464524 0.83 CA12 (0.61) ALDH1A1GAASMN1; SMN2KDM4ERAB9A
SCHEMBL7383813 0.83 ALDH1A1 (0.71) ALDH1A1GAASMN1; SMN2KDM4ENPC1
SCHEMBL29764444 0.82 ALDH1A1 (0.60) ALDH1A1GAASMN1; SMN2KDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240399776-A1 COLOR DEVELOPER, THERMAL RECORDING MATERIAL, AND THERMAL RECORDING LAYER COATING MATERIAL SANKO CO., LTD. (JP) 2024-12-05 US disclosed
EP-4269119-A1 COLOR DEVELOPER, HEAT-SENSITIVE RECORDING MATERIAL, AND COATING MATERIAL FOR HEAT-SENSITIVE RECORDING LAYERS Sanko Co., Ltd. (JP) 2023-11-01 EP disclosed
EP-3342599-B1 HEAT-SENSITIVE RECORDING MATERIAL SANKO CO LTD (JP) 2021-06-16 EP disclosed
US-10086634-B2 Heat-sensitive recording material SANKO CO., LTD. (JP) 2018-10-02 US disclosed
US-20180194151-A1 HEAT-SENSITIVE RECORDING MATERIAL SANKO CO., LTD. (JP) 2018-07-12 US disclosed
EP-3342599-A1 HEAT-SENSITIVE RECORDING MATERIAL Sanko Co., Ltd. (JP) 2018-07-04 EP disclosed
CN-1720238-B Neurologically-active compounds PRANA BIOTECHNOLOGY LTD 2011-08-03 CN disclosed
EP-2210892-A2 Neurologically-active compounds Prana Biotechnology Limited (AU) 2010-07-28 EP disclosed
US-20100160346-A1 NEUROLOGICALLY ACTIVE COMPOUNDS PRANA BIOTECHNOLOGY LIMITED (AU) 2010-06-24 US disclosed
US-7692011-B2 8-hydroxy and 8-mercapto quinazolinones PRANA BIOTECHNOLOGY LIMITED (AU) 2010-04-06 US disclosed
CN-1720238-A Neurologically-active compounds PRANA BIOTECHNOLOGY LTD (AU) 2006-01-11 CN disclosed
EP-1558585-A1 NEUROLOGICALLY-ACTIVE COMPOUNDS Prana Biotechnology Ltd (AU) 2005-08-03 EP disclosed
WO-2004031161-A1 NEUROLOGICALLY-ACTIVE COMPOUNDS PRANA BIOTECHNOLOGY LIMITED (AU) 2004-04-15 WO disclosed
EP-0885205-A4 FIBRINOGEN RECEPTOR ANTAGONISTS MERCK & CO INC (US) 2002-11-27 EP disclosed
EP-0885205-A1 FIBRINOGEN RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 1998-12-23 EP disclosed
EP-0811001-A1 BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1997-12-10 EP disclosed
WO-1997031910-A1 FIBRINOGEN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1997-09-04 WO disclosed
US-4283416-A Fungicidal, miticidal and ovicidal alkoxycarbonylalkyl-substituted and carbamylalkyl-substituted N-haloalkylthiosulfonamides CHEVRON RESEARCH COMPANY (US) 1981-08-11 US disclosed
US-4230875-A Fungicidal, miticidal and ovicidal alkoxycarbonylalkyl-substituted and carbamylalkyl-substituted N-haloalkylthiosulfonamides CHEVRON RESEARCH COMPANY (US) 1980-10-28 US disclosed
US-4112237-A Fungicidal, miticidal and ovicidal alkoxycarbonylalkyl-substituted and carbamylalkyl-substituted N-haloalkylthiosulfonamides CHEVRON RESEARCH COMPANY (US) 1978-09-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180194151-A1 HEAT-SENSITIVE RECORDING MATERIAL ASIC1, SCN1A, NPR1 ALDH1A1 1820/4885GAA 4169/4885SMN1; SMN2 871/4885
US-10086634-B2 Heat-sensitive recording material ASIC1, SCN1A, NPR1 ALDH1A1 1666/4885GAA 4231/4885SMN1; SMN2 873/4885
US-20100160346-A1 NEUROLOGICALLY ACTIVE COMPOUNDS ACHE, PSEN1, PSEN2 ALDH1A1 703/4885GAA 24/4885SMN1; SMN2 20/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.