Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.32 |
| ▸ | TKT | P29401 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4648511 | 0.86 | PDXK (0.38) | DHFRGABRA1GABRB1P2RX3P2RX2 | |
| SCHEMBL16879557 | 0.76 | RECQL (0.35) | RECQL | |
| SCHEMBL23970881 | 0.75 | GABRA1 (0.39) | GABRA1GABRB1P2RX3P2RX2LMNA | |
| SCHEMBL5708632 | 0.75 | P2RX3 (0.31) | DHFRP2RX3P2RX2 | |
| SCHEMBL38666717 | 0.74 | PDXK (0.40) | GABRA1GABRB1RECQLLMNA | |
| SCHEMBL4649636 | 0.73 | PDCD1LG2 (0.35) | DHFRP2RX3P2RX2 | |
| SCHEMBL4648719 | 0.72 | GABRA1 (0.39) | GABRA1GABRB1LMNA | |
| SCHEMBL2737360 | 0.71 | GABRA1 (0.37) | GABRA1GABRB1P2RX3P2RX2LMNA | |
| SCHEMBL18353218 | 0.71 | GABRA1 (0.39) | GABRA1GABRB1P2RX3P2RX2LMNA | |
| SCHEMBL2738317 | 0.70 | LMNA (0.40) | DHFRGABRA1GABRB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718613-A1 | PYRIDINE DERIVATIVES AND THEIR USE AS CB2 RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005080342-A1 | PYRIDINE DERIVATIVES AND THEIR USE AS CB2 RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2005-09-01 | — | — | WO | disclosed |