Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 19/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5532802 | 0.84 | ADRB2 (0.57) | ADRB2ADRB1DRD3DRD2ABCB11 | |
| SCHEMBL3833821 | 0.80 | ADRB2 (0.56) | ADRB2ADRB1DRD3DRD2 | |
| SCHEMBL5115580 | 0.79 | ADRB2 (0.40) | ADRB2ADRB1DRD2ABCB11PDE4A | |
| SCHEMBL3836095 | 0.77 | ADRB2 (0.43) | ADRB2ADRB1DRD3DRD2 | |
| SCHEMBL3834974 | 0.73 | ADRB2 (0.82) | ADRB2ADRB1DRD3DRD2 | |
| SCHEMBL4753883 | 0.69 | ADRB2 (0.50) | ADRB2ADRB1DRD3DRD2 | |
| SCHEMBL3886067 | 0.69 | ADRB2 (0.50) | ADRB2ADRB1DRD2ABCB11PDE4A | |
| SCHEMBL7828879 | 0.69 | ABCB11 (0.77) | ADRB2ADRB1DRD2ABCB11PDE4A | |
| SCHEMBL7836713 | 0.69 | ABCB11 (0.62) | ADRB2ADRB1DRD2ABCB11PDE4A | |
| Hydrochloric Acid SCHEMBL7843998 | 0.69 | ABCB11 (0.75) | ADRB2ADRB1DRD2ABCB11PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1715860-A1 | COMBINATION OF BENZOTHIAZOL-2-ONE BETA2 ADRENOCEPTOR AGONISTS AND CORTICOSTEROIDS FOR THE TREATMENT OF RESPIRATORY DISEASES | Novartis AG (CH) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005074924-A1 | COMBINATION OF BENZOTHIAZOL-2-ONE BETA2 ADRENOCEPTOR AGONISTS AND CORTICOSTEROIDS FOR THE TREATMENT OF RESPIRATORY DISEASES | NOVARTIS AG (CH) | 2005-08-18 | — | — | WO | disclosed |
| EP-1529038-A1 | BENZOTHIAZOLE DERIVATIVES HAVING BETA-2-ADRENORECEPTOR AGONIST ACTIVITY | Novartis AG (CH) | 2005-05-11 | — | — | EP | disclosed |
| WO-2004016601-A1 | BENZOTHIAZOLE DERIVATIVES HAVING BETA-2-ADRENORECEPTOR AGONIST ACTIVITY | NOVARTIS AG (CH) | 2004-02-26 | — | — | WO | disclosed |