Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 known ✓ | Q96DB2 | 5/20 | 0.44 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.65 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.65 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.65 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 6/20 | 0.44 |
| ▸ | PPARD | Q03181 | 6/20 | 0.44 |
| ▸ | PPARA | Q07869 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL3038365 | 0.98 | GPR84 (0.70) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| 1,6-Hexanediol SCHEMBL3482818 | 0.98 | GPR84 (0.70) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| Oxybate SCHEMBL1643115 | 0.93 | CAMK2A (0.67) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| Succinic Acid SCHEMBL194813 | 0.93 | GPR84 (0.54) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| Adipic Acid SCHEMBL5306019 | 0.91 | LMNA (0.61) | GPR84FFAR1FFAR4LMNATP53 | |
| Hexanoate SCHEMBL4269371 | 0.90 | GPR84 (0.63) | GPR84FFAR1FFAR4TSHRAKR1B1 | |
| Lactic Acid SCHEMBL3482989 | 0.90 | GPR84 (0.59) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| Adipic Acid SCHEMBL29201122 | 0.88 | GPR84 (0.68) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| Lactic Acid SCHEMBL8850880 | 0.88 | TP53 (0.65) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| Lactic Acid SCHEMBL11019396 | 0.88 | TP53 (0.65) | GPR84FFAR1FFAR4CAMK2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1702672-A1 | Dispersants | The Lubrizol Corporation (US) | 2006-09-20 | — | — | EP | claimed |
| EP-1276553-A2 | DISPERSANTS | Avecia Limited (GB) | 2003-01-22 | — | — | EP | claimed |
| WO-2001080987-A2 | DISPERSANTS | AVECIA LIMITED (GB) | 2001-11-01 | — | — | WO | claimed |
| EP-0786492-B1 | Method for disposal of a plastic molded product | MATSUSHITA ELECTRIC INDUSTRIAL CO LTD (JP) | 2004-12-15 | — | — | EP | disclosed |
| US-5874482-A | IMMERSING SAID THERMOSET PLASTIC MOLDED PRODUCT IN AN ALKALINE AQUEOUS SOLUTION TO PROMOTE PERMEATION AND PENETRATION OF SAID ALKALINE AQUEOUS SOLUTION INTO SAID THERMOSET PLASTIC MOLDED PRODUCT, CAUSING SOFTENING, WEAKENING | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1999-02-23 | — | — | US | disclosed |
| EP-0786492-A2 | Plastic molded product and method for disposal of the same | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |