Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 known ✓ | Q96DB2 | 5/20 | 0.42 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.59 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.59 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 6/20 | 0.42 |
| ▸ | PPARD | Q03181 | 6/20 | 0.42 |
| ▸ | PPARA | Q07869 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TLR2 | O60603 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | FABP4 | P15090 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sebacic Acid SCHEMBL29010944 | 0.94 | TSHR (0.50) | GPR84FFAR1FFAR4TSHRLMNA | |
| 1,6-Hexanediol SCHEMBL3482818 | 0.92 | GPR84 (0.70) | GPR84FFAR1FFAR4CAMK2ATSHR | |
| Lactic Acid SCHEMBL3038365 | 0.92 | GPR84 (0.70) | GPR84FFAR1FFAR4CAMK2ATSHR | |
| Lactic Acid SCHEMBL5709392 | 0.90 | GPR84 (0.65) | GPR84FFAR1FFAR4CAMK2ATSHR | |
| Stearic Acid SCHEMBL868974 | 0.87 | FFAR4 (0.62) | GPR84FFAR1FFAR4TSHRPPARG | |
| Dodecanoate SCHEMBL28201984 | 0.87 | FFAR4 (0.62) | GPR84FFAR1FFAR4TSHRPPARG | |
| Palmitic Acid SCHEMBL27622253 | 0.87 | FFAR4 (0.62) | GPR84FFAR1FFAR4TSHRPPARG | |
| Adipic Acid SCHEMBL10919803 | 0.86 | FFAR1 (0.65) | GPR84FFAR1FFAR4CAMK2ATSHR | |
| Hexanoate SCHEMBL4261291 | 0.85 | FFAR4 (0.59) | GPR84FFAR1FFAR4TSHRPPARG | |
| Hexanoate SCHEMBL4269371 | 0.85 | GPR84 (0.63) | GPR84FFAR1FFAR4TSHRPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130345260-A1 | High Viscosity Liquid Controlled Delivery System and Medical or Surgical Device | DURECT CORPORATION (US) | 2013-12-26 | — | — | US | disclosed |
| US-7833543-B2 | Sustained release of active materials; storage stability | DURECT CORPORATION (US) | 2010-11-16 | — | — | US | disclosed |
| US-20080145419-A1 | High viscosity liquid controlled delivery system and medical or surgical device | DURECT CORPORATION | 2008-06-19 | — | — | US | disclosed |
| US-20060210599-A1 | Injectable or sprayable nonpolymeric ester or mixed ester solution easily formulated with therapeutic agents | GIBSON JOHN W | 2006-09-21 | — | — | US | disclosed |
| EP-1212092-B1 | HIGH VISCOSITY LIQUID CONTROLLED DELIVERY SYSTEM AND MEDICAL OR SURGICAL DEVICE | DURECT CORP (US) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004052336-A2 | HIGH VISCOSITY LIQUID CONTROLLED DELIVERY SYSTEM AND MEDICAL OR SURGICAL DEVICE | DURECT CORPORATION (US) | 2004-06-24 | — | — | WO | disclosed |
| US-20040101557-A1 | High viscosity liquid controlled delivery system and medical or surgical device | DURECT CORPORATION | 2004-05-27 | — | — | US | disclosed |
| US-6413536-B1 | DELIVERING ACTIVE MATERIALS | SOUTHERN BIOSYSTEMS, INC. | 2002-07-02 | — | — | US | disclosed |
| EP-1212092-A2 | HIGH VISCOSITY LIQUID CONTROLLED DELIVERY SYSTEM AND MEDICAL OR SURGICAL DEVICE | Southern Biosystems, Inc. (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001015734-A2 | HIGH VISCOSITY LIQUID CONTROLLED DELIVERY SYSTEM AND MEDICAL OR SURGICAL DEVICE | SOUTHERN BIOSYSTEMS, INC. (US) | 2001-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060210599-A1 | Injectable or sprayable nonpolymeric ester or mixed ester solution easily formulated with therapeutic agents | MMP1, MMP11, MMP13 | HDAC11 3085/4885PDE3A 68/4885GPR84 1897/4885 |
| US-20040101557-A1 | High viscosity liquid controlled delivery system and medical or surgical device | MMP1, MMP13, MMP9 | HDAC11 4568/4885PDE3A 147/4885GPR84 2110/4885 |
| US-20130345260-A1 | High Viscosity Liquid Controlled Delivery System and Medical or Surgical Device | MMP1, MMP13, MMP9 | HDAC11 4615/4885PDE3A 156/4885GPR84 2124/4885 |
| US-20080145419-A1 | High viscosity liquid controlled delivery system and medical or surgical device | MMP1, MMP13, MMP9 | HDAC11 4568/4885PDE3A 147/4885GPR84 2110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.