Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 7/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 7/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944465 | 0.90 | KCNK3 (0.44) | KCNK3KCNK9ABL1EGFRPDGFRB | |
| SCHEMBL1386047 | 0.87 | CASR (0.44) | KCNK3KCNK9ABL1EGFRPDGFRB | |
| SCHEMBL1386196 | 0.81 | PDK1 (0.43) | MAPK1POLBKMT2AKDM4ELMNA | |
| SCHEMBL3944917 | 0.79 | BACE1 (0.41) | KCNK3KCNK9ABL1PDGFRBBCR | |
| SCHEMBL3946988 | 0.78 | MEN1 (0.47) | KCNK3KCNK9POLBKMT2AKDM4E | |
| SCHEMBL1383618 | 0.78 | ALOX5 (0.47) | MAPK1KMT2ALMNAALDH1A1HPGD | |
| SCHEMBL3951861 | 0.78 | GRM4 (0.41) | KCNK3KCNK9ABL1BCRBACE1 | |
| SCHEMBL3442836 | 0.77 | ALOX5 (0.40) | MAPK1POLBKMT2AKDM4EALDH1A1 | |
| SCHEMBL3944601 | 0.75 | KCNK3 (0.44) | KCNK3ABL1PDGFRBBCRPDGFRA | |
| SCHEMBL3951875 | 0.75 | MAPT (0.42) | KCNK3KCNK9ABL1PDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718632-A1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | Sanofi-Aventis (FR) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005075458-A1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTORS ANTAGONISTS | SANOFI-AVENTIS (FR) | 2005-08-18 | — | — | WO | disclosed |