Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 10/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5711073 | 0.91 | RAB9A (0.52) | METPDGFRAKITKDRRAB9A | |
| SCHEMBL6031858 | 0.89 | MET (0.60) | METPDGFRACSF1RPDGFRBFLT3 | |
| SCHEMBL4330450 | 0.83 | MET (0.68) | METPDGFRAKITCSF1RPDGFRB | |
| SCHEMBL5711096 | 0.82 | MET (0.45) | METRAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4330444 | 0.81 | MET (0.54) | METPDGFRAKITCSF1RPDGFRB | |
| SCHEMBL9958089 | 0.79 | MET (0.60) | METPDGFRAPDGFRBKDR | |
| SCHEMBL4335458 | 0.77 | KDR (0.44) | METPDGFRACSF1RPDGFRBFLT3 | |
| SCHEMBL5711089 | 0.77 | KMT2A (0.46) | METRAB9AMAPTNPC1POLB | |
| SCHEMBL9958429 | 0.77 | MET (0.58) | METKDRRAB9APOLBBRAF | |
| SCHEMBL13861117 | 0.76 | KDR (0.49) | METPDGFRAKITCSF1RPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1719763-A1 | NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (2) | Eisai Co., Ltd. (JP) | 2006-11-08 | — | — | EP | disclosed |
| EP-1719762-A1 | NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (1) | Eisai Co., Ltd. (JP) | 2006-11-08 | — | — | EP | disclosed |