Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rel-Menthone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 3/20 | 0.53 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rel-Menthone SCHEMBL744217 | 0.91 | TRPM8 (0.64) | TRPM8TRPA1EPHX1ALDH1A1TRPV1 | |
| Menthone SCHEMBL80560 | 0.87 | NPC1 (0.33) | LMNAALDH1A1 | |
| Rel-Menthone SCHEMBL80559 | 0.87 | NPC1 (0.33) | LMNAALDH1A1 | |
| Menthone SCHEMBL1031003 | 0.87 | NPC1 (0.33) | LMNAALDH1A1 | |
| Menthol SCHEMBL1617429 | 0.84 | TRPM8 (0.75) | TRPM8TRPA1EPHX1LMNAGAA | |
| Rel-Menthone SCHEMBL3636289 | 0.83 | NPC1 (0.34) | — | |
| Menthone SCHEMBL3636290 | 0.83 | NPC1 (0.34) | — | |
| Menthol SCHEMBL2634088 | 0.81 | TRPM8 (0.66) | TRPM8TRPA1EPHX1LMNAMAPT | |
| Rel-Menthone SCHEMBL111746 | 0.80 | LMNA (0.32) | LMNACYP2D6 | |
| Menthone SCHEMBL3652908 | 0.80 | LMNA (0.32) | LMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117582375-A | Antipruritic composition and preparation method and application thereof | 深圳杉海创新技术有限公司 | 2024-02-23 | — | — | CN | claimed |
| CN-117582375-A | Antipruritic composition and preparation method and application thereof | 深圳杉海创新技术有限公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-117582375-A | Antipruritic composition and preparation method and application thereof | 深圳杉海创新技术有限公司 | 2024-02-23 | — | — | CN | disclosed |
| EP-1682641-A1 | FLAVOR INGREDIENTS FOR COOLING PREPARATIONS | FIRMENICH SA (CH) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005042680-A1 | FLAVOR INGREDIENTS FOR COOLING PREPARATIONS | FIRMENICH SA (CH) | 2005-05-12 | — | — | WO | disclosed |