Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | ME2 | P23368 | 3/20 | 0.39 |
| ▸ | ME1 | P48163 | 3/20 | 0.39 |
| ▸ | ME3 | Q16798 | 3/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5714722 | 0.91 | PANK3 (0.42) | PANK3HRH3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5714403 | 0.89 | PANK3 (0.42) | PANK3HRH3SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL5715040 | 0.89 | TRPA1 (0.44) | PANK3SMN1; SMN2ALDH1A1MAPTMAPK1 | |
| SCHEMBL5715347 | 0.88 | HRH3 (0.41) | PANK3HRH3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5715000 | 0.88 | PANK3 (0.41) | PANK3HRH3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5714742 | 0.87 | SMN1; SMN2 (0.53) | HRH3SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL5715306 | 0.86 | HSD17B10 (0.51) | SMN1; SMN2KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL5714025 | 0.85 | SMN1; SMN2 (0.41) | PANK3SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL5714702 | 0.84 | THRB (0.39) | SMN1; SMN2KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL5715243 | 0.83 | PANK3 (0.52) | PANK3HRH3SMN1; SMN2ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060160819-A1 | Substitued piperazine carbamates | NOVO NORDISK A/S (DK) | 2006-07-20 | — | — | US | claimed |
| EP-1636189-A1 | 1-ARYL-4-(ARYLOXYCARBONYL)-PIPERAZINE DERIVATIVES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004111007-A1 | 1-ARYL-4-(ARYLOXYCARBONYL)-PIPERAZINE DERIVATIVES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160819-A1 | Substitued piperazine carbamates | LIPE, PNLIP, LIPC | PANK3 1247/4885HRH3 1098/4885SMN1; SMN2 2732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.