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SCHEMBL5714922

SCHEMBL5714922

Cc1nc(CCN2CCN(C(=O)Oc3ccc(N4C(=O)C5CCCCC5C4=O)cn3)CC2)cs1

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.36
▸ SMN1; SMN2 Q16637 3/20 0.36
▸ MAPT P10636 2/20 0.36
▸ LMNA P02545 1/20 0.36
▸ POLB P06746 1/20 0.36
▸ KMT2A Q03164 4/20 0.35
▸ PKM P14618 2/20 0.34
▸ GAA P10253 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ CHRM4 P08173 1/20 0.34
▸ MEN1 O00255 1/20 0.33
▸ L3MBTL1 Q9Y468 2/20 0.33
▸ CYP4F2 P78329 1/20 0.33
▸ KCNH2 Q12809 1/20 0.32
▸ SIGMAR1 Q99720 1/20 0.32
▸ HRH2 P25021 1/20 0.32
▸ HRH1 P35367 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5714200 0.86 KCNH2 (0.39) ALDH1A1SMN1; SMN2MAPTLMNAPOLB
SCHEMBL5715004 0.86 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2MAPTLMNAPOLB
SCHEMBL5715197 0.84 XIAP (0.37) ALDH1A1SMN1; SMN2MAPTLMNAPOLB
SCHEMBL5714669 0.84 KMT2A (0.36) ALDH1A1SMN1; SMN2LMNAKMT2APKM
SCHEMBL5714599 0.84 ALDH1A1 (0.36) ALDH1A1SMN1; SMN2MAPTLMNAPOLB
SCHEMBL5715472 0.83 ALDH1A1 (0.36) ALDH1A1SMN1; SMN2MAPTLMNAPOLB
SCHEMBL5715222 0.83 THRB (0.46) ALDH1A1LMNAKMT2AL3MBTL1KCNH2
SCHEMBL5714337 0.82 ALDH1A1 (0.42) ALDH1A1SMN1; SMN2MAPTLMNAPOLB
SCHEMBL5715303 0.81 SMN1; SMN2 (0.36) ALDH1A1SMN1; SMN2MAPTLMNAPOLB
SCHEMBL5714497 0.81 ALDH1A1 (0.37) ALDH1A1SMN1; SMN2MAPTLMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2006527212-A — — 2006-11-30 — — JP claimed
US-20060160820-A1 Substituted piperazine carbamates NOVO NORDISK A/S (DK) 2006-07-20 — — US claimed
EP-1636187-A1 SUBSTITUTED PIPERAZINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2006-03-22 — — EP claimed
WO-2004111004-A1 SUBSTITUTED PIPERAZINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-12-23 — — WO claimed
US-20060160820-A1 Substituted piperazine carbamates NOVO NORDISK A/S (DK) 2006-07-20 — — US disclosed
EP-1636187-A1 SUBSTITUTED PIPERAZINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2006-03-22 — — EP disclosed
WO-2004111004-A1 SUBSTITUTED PIPERAZINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-12-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060160820-A1 Substituted piperazine carbamates LIPE, PNLIP, LPL ALDH1A1 1504/4885SMN1; SMN2 3125/4885MAPT 4348/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.