Sugi Predict

Sugi Predict / Compounds / SCHEMBL5717721

SCHEMBL5717721

SCHEMBL5717721

O=C(O)c1ccnn(-c2ccccc2)c1=O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.47
▸ SMN1; SMN2 Q16637 3/20 0.47
▸ POLB P06746 2/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ NR4A3 Q92570 1/20 0.47
▸ KEAP1 Q14145 1/20 0.46
▸ NFE2L2 Q16236 1/20 0.46
▸ ALDH1A1 P00352 3/20 0.45
▸ NPC1 O15118 2/20 0.45
▸ HTT P42858 2/20 0.45
▸ RAB9A P51151 2/20 0.45
▸ PAX8 Q06710 2/20 0.45
▸ NPSR1 Q6W5P4 2/20 0.45
▸ MITF O75030 1/20 0.45
▸ S1PR4 O95977 1/20 0.45
▸ THRB P10828 1/20 0.45
▸ XBP1 P17861 1/20 0.45
▸ S1PR1 P21453 1/20 0.45
▸ LMNA P02545 1/20 0.45
▸ RXFP1 Q9HBX9 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5189021 0.86 RIPK2 (0.55) MAPTSMN1; SMN2POLBALDH1A1NPC1
SCHEMBL680352 0.85 AXL (0.47) L3MBTL1ALDH1A1LMNAKDM4EMAPK14
SCHEMBL30449848 0.81 KDM5A (0.44) MAPTSMN1; SMN2POLBNR4A3ALDH1A1
SCHEMBL3101175 0.80 ALKBH2 (0.47) MAPTSMN1; SMN2L3MBTL1ALDH1A1NPC1
SCHEMBL318890 0.79 MAPK14 (0.47) SMN1; SMN2ALDH1A1KDM4EMAPK14
SCHEMBL13101587 0.79 RIPK1 (0.51) MAPTSMN1; SMN2POLBALDH1A1HTT
SCHEMBL12376647 0.79 PDE4A (0.49) MAPTPOLBGAA
SCHEMBL28391996 0.78 POLB (0.50) MAPTSMN1; SMN2POLBALDH1A1NPC1
SCHEMBL12988044 0.78 KEAP1 (0.38) MAPTSMN1; SMN2POLBKEAP1NFE2L2
SCHEMBL25340632 0.77 TSHR (0.43) SMN1; SMN2L3MBTL1ALDH1A1RAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3762392-B1 THIENOPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME WELLMARKER BIO CO LTD (KR) 2024-05-15 — — EP disclosed
US-11447500-B2 Thienopyridine derivatives and pharmaceutical composition comprising same WELLMARKER BIO CO., LTD. (KR) 2022-09-20 — — US disclosed
US-20220288043-A1 THIENOPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME WELLMARKER BIO CO, LTD. (KR) 2022-09-15 — — US disclosed
CN-111295386-B Thienopyridine derivatives and pharmaceutical compositions containing the same 伟迈可生物有限公司 2022-09-06 — — CN disclosed
US-20210317133-A1 THIENOPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME WELLMARKER BIO CO., LTD. (KR) 2021-10-14 — — US disclosed
US-20210317133-A1 THIENOPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME WELLMARKER BIO CO., LTD. (KR) 2021-10-14 — — US disclosed
EP-3762392-A1 THIENOPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME Wellmarker Bio Co., Ltd. (KR) 2021-01-13 — — EP disclosed
CN-111295386-A Thienopyridine derivatives and pharmaceutical compositions containing the same 伟迈可生物有限公司 2020-06-16 — — CN disclosed
WO-2019182274-A1 THIENOPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME WELLMARKER BIO CO., LTD. (KR) 2019-09-26 — — WO disclosed
WO-2019182274-A1 THIENOPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME WELLMARKER BIO CO., LTD. (KR) 2019-09-26 — — WO disclosed
US-9439428-B2 Herbicidal compounds SYNGENTA LIMITED (GB) 2016-09-13 — — US disclosed
US-20150230468-A1 HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2015-08-20 — — US disclosed
US-9035049-B2 Herbicidal compounds SYNGENTA LIMITED (GB) 2015-05-19 — — US disclosed
EP-2694483-B1 HERBICIDAL COMPOUNDS SYNGENTA LTD (GB) 2015-03-04 — — EP disclosed
EP-2694483-A1 HERBICIDAL COMPOUNDS Syngenta Limited (GB) 2014-02-12 — — EP disclosed
US-20140031223-A1 HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2014-01-30 — — US disclosed
WO-2012136703-A1 HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2012-10-11 — — WO disclosed
EP-1363925-B1 MACROLIDE ANTIBIOTICS GLAXO GROUP LTD (GB) 2006-11-15 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140031223-A1 HERBICIDAL COMPOUNDS DDT, CBR3, RDX MAPT 4213/4885SMN1; SMN2 4232/4885POLB 4033/4885
US-11447500-B2 Thienopyridine derivatives and pharmaceutical composition comprising same MAP4K5, MAP4K2, MAP3K9 MAPT 1090/4885SMN1; SMN2 1947/4885POLB 2754/4885
US-20150230468-A1 HERBICIDAL COMPOUNDS DDT, CBR3, RDX MAPT 4213/4885SMN1; SMN2 4232/4885POLB 4033/4885
US-20210317133-A1 THIENOPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME MAP4K5, MAP4K2, MAP3K9 MAPT 1090/4885SMN1; SMN2 1947/4885POLB 2754/4885
US-20220288043-A1 THIENOPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME PRKACA, MAP4K5, MAPKAPK5 MAPT 1304/4885SMN1; SMN2 1450/4885POLB 3620/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.