Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 8/20 | 0.35 |
| ▸ | THRB | P10828 | 8/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5722615 | 0.90 | MEN1 (0.40) | THRATHRBMRGPRX4ALDH1A1MEN1 | |
| SCHEMBL5717877 | 0.90 | THRA (0.36) | THRATHRBMRGPRX4ALDH1A1MEN1 | |
| SCHEMBL5718069 | 0.89 | ALDH1A1 (0.38) | THRATHRBMRGPRX4ALDH1A1MEN1 | |
| SCHEMBL4930968 | 0.88 | ALDH1A1 (0.42) | THRATHRBMRGPRX4ALDH1A1MEN1 | |
| SCHEMBL4931585 | 0.88 | THRB (0.43) | THRATHRBALDH1A1TRPA1DHODH | |
| SCHEMBL4933325 | 0.88 | THRB (0.43) | THRATHRBDHODH | |
| SCHEMBL4933128 | 0.88 | TRPA1 (0.41) | THRATHRBMRGPRX4ALDH1A1MEN1 | |
| SCHEMBL4932487 | 0.87 | MEN1 (0.37) | THRATHRBMRGPRX4MEN1KMT2A | |
| SCHEMBL5718012 | 0.87 | THRA (0.38) | THRATHRBMRGPRX4ALDH1A1MEN1 | |
| SCHEMBL4933736 | 0.86 | ALDH1A1 (0.44) | THRATHRBMRGPRX4ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732533-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092317-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |