Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | AKT2 | P31751 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6018652 | 0.84 | ALDH1A1 (0.36) | ALDH1A1HPGDMAPTTDP1KDM4E | |
| SCHEMBL3290015 | 0.81 | ALDH1A1 (0.36) | ALDH1A1HPGDMAPTTDP1KDM4E | |
| SCHEMBL5718140 | 0.77 | MAPK1 (0.35) | ALDH1A1HPGDMAPTTDP1KDM4E | |
| SCHEMBL6018836 | 0.67 | PTGS2 (0.39) | ALDH1A1HPGDMAPTTDP1LMNA | |
| SCHEMBL8092992 | 0.66 | TDP1 (0.31) | ALDH1A1TDP1KDM4E | |
| SCHEMBL6018662 | 0.66 | PTGS2 (0.40) | ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL13337266 | 0.66 | AKT2 (0.46) | ALDH1A1HPGDMAPTTDP1KDM4E | |
| SCHEMBL6018296 | 0.65 | MAPK1 (0.37) | ALDH1A1HPGDMAPTTDP1KDM4E | |
| SCHEMBL5718215 | 0.64 | ALDH1A1 (0.34) | ALDH1A1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL7616904 | 0.64 | PRCP (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141637-B2 | Metallocene compounds and process for the preparation of propylene polymers | BASELL POLYOLEFINE GMBH (DE) | 2006-11-28 | — | — | US | disclosed |
| EP-1448578-B1 | METALLOCENE COMPOUNDS AND PROCESS FOR THE PREPARATION OF PROPYLENE POLYMERS | BASELL POLYOLEFINE GMBH (DE) | 2006-07-26 | — | — | EP | disclosed |
| US-20050010058-A1 | Such as {Dimethyl-silyl-(5-isopropyl-2-methyl-3-phenyl-cyclopento[2,3-b]thiophen-6-yl)-(2-methyl-4-phenyl-[3a,4-dihydro]azulen-1-yl)}ZrCl2 catalyst for homo or copolymerization of propylene | EXXONMOBIL CHEMICAL PATENTS INC. | 2005-01-13 | — | — | US | disclosed |
| EP-1448578-A1 | METALLOCENE COMPOUNDS AND PROCESS FOR THE PREPARATION OF PROPYLENE POLYMERS | Basell Polyolefine GmbH (DE) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003045964-A1 | METALLOCENE COMPOUNDS AND PROCESS FOR THE PREPARATION OF PROPYLENE POLYMERS | BASELL POLYOLEFINE GMBH (DE) | 2003-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050010058-A1 | Such as {Dimethyl-silyl-(5-isopropyl-2-methyl-3-phenyl-cyclopento[2,3-b]thiophen-6-yl)-(2-methyl-4-phenyl-[3a,4-dihydro]azulen-1-yl)}ZrCl2 catalyst for homo or copolymerization of propylene | CHRM1, YWHAZ, PYM1 | ALDH1A1 2017/4885HPGD 1848/4885MAPT 4468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.