Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | GRM6 | O15303 | 5/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 4/20 | 0.31 |
| ▸ | TP53 | P04637 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3290015 | 0.85 | ALDH1A1 (0.36) | PTGS2CHEK1AKT2PTGS1MAPT | |
| SCHEMBL6018662 | 0.83 | PTGS2 (0.40) | PTGS2GRM6MAPTTP53ALDH1A1 | |
| SCHEMBL1827223 | 0.73 | PTGS2 (0.39) | PTGS2GRM6ALOX5CHEK1AKT2 | |
| SCHEMBL6018652 | 0.71 | ALDH1A1 (0.36) | PTGS2CHEK1AKT2PTGS1MAPT | |
| SCHEMBL4314296 | 0.69 | LIMK1 (0.38) | PTGS2PTGS1 | |
| SCHEMBL3292309 | 0.67 | GPR3 (0.41) | MAPTALDH1A1MEN1NFKB1RAB9A | |
| SCHEMBL5718215 | 0.67 | ALDH1A1 (0.34) | MAPTALDH1A1HTTNPC1LMNA | |
| SCHEMBL5718213 | 0.67 | ALDH1A1 (0.33) | CHEK1AKT2MAPTALDH1A1NPC1 | |
| SCHEMBL1224397 | 0.66 | MAPT (0.56) | PTGS2GRM6ALOX5CHEK1AKT2 | |
| SCHEMBL10109209 | 0.66 | ALOX5 (0.42) | PTGS2GRM6ALOX5CHEK1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412347-B1 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC PENTALENE DERIVATIVES | BASELL POLYOLEFINE GMBH (DE) | 2006-01-11 | — | — | EP | disclosed |
| US-6930190-B2 | Process for the preparation of heterocyclic pentalene derivatives | BASELL POLYOLEFINE GMBH (DE) | 2005-08-16 | — | — | US | disclosed |
| US-20040192931-A1 | Process for the preparation of heterocyclic pentalene derivatives | EQUISTAR CHEMICALS, LP | 2004-09-30 | — | — | US | disclosed |
| EP-1412347-A1 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC PENTALENE DERIVATIVES | Basell Polyolefine GmbH (DE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003014107-A1 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC PENTALENE DERIVATIVES | BASELL POLYOLEFINE GMBH (DE) | 2003-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192931-A1 | Process for the preparation of heterocyclic pentalene derivatives | CBR3, CBR1, ADH5 | PTGS2 268/4885GRM6 2066/4885ALOX5 352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.