Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.36 |
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1824700 | 0.84 | MAPK1 (0.38) | MAPK1ALDH1A1HPGDMAPTTDP1 | |
| SCHEMBL6019765 | 0.83 | PTGS2 (0.40) | PTGS2L3MBTL1 | |
| SCHEMBL5718140 | 0.79 | MAPK1 (0.35) | MAPK1ALDH1A1HPGDMAPTTDP1 | |
| SCHEMBL1827223 | 0.71 | PTGS2 (0.39) | MAPK1ALDH1A1HPGDMAPTTDP1 | |
| SCHEMBL13337266 | 0.70 | AKT2 (0.46) | MAPK1ALDH1A1HPGDMAPTTDP1 | |
| SCHEMBL3290015 | 0.69 | ALDH1A1 (0.36) | MAPK1ALDH1A1HPGDMAPTTDP1 | |
| SCHEMBL27546185 | 0.68 | ALDH1A1 (0.40) | ALDH1A1HPGDLMNANPC1RAB9A | |
| SCHEMBL25245248 | 0.68 | PTGS2 (0.33) | ALDH1A1HPGDMAPTKDM4ENPC1 | |
| SCHEMBL25289822 | 0.67 | IKBKB (0.38) | ALDH1A1HPGDMAPTTDP1SMN1; SMN2 | |
| SCHEMBL6018873 | 0.67 | PTGS2 (0.34) | ALDH1A1MAPTSMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412347-B1 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC PENTALENE DERIVATIVES | BASELL POLYOLEFINE GMBH (DE) | 2006-01-11 | — | — | EP | disclosed |
| US-6930190-B2 | Process for the preparation of heterocyclic pentalene derivatives | BASELL POLYOLEFINE GMBH (DE) | 2005-08-16 | — | — | US | disclosed |
| US-20040192931-A1 | Process for the preparation of heterocyclic pentalene derivatives | EQUISTAR CHEMICALS, LP | 2004-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192931-A1 | Process for the preparation of heterocyclic pentalene derivatives | CBR3, CBR1, ADH5 | MAPK1 591/4885ALDH1A1 805/4885HPGD 330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.