SCHEMBL5720001

SCHEMBL5720001

Cc1ccsc1CN1CCC(N2CCC(c3cc4c(cc3Br)[N]C(=O)N4)CC2)CC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.34
CHRM1 P11229 6/20 0.34
KDM4E B2RXH2 5/20 0.34
DRD2 P14416 3/20 0.34
CHRM2 P08172 2/20 0.34
CHRM3 P20309 2/20 0.34
CHRM4 P08173 1/20 0.34
CHRM5 P08912 1/20 0.34
ADRA1D P25100 1/20 0.34
HTR2C P28335 1/20 0.34
ADRA1A P35348 1/20 0.34
ADRA1B P35368 1/20 0.34
LMNA P02545 1/20 0.32
POLB P06746 1/20 0.32
DRD4 P21917 2/20 0.31
TSHR P16473 1/20 0.30
RECQL P46063 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
KCNH2 Q12809 1/20 0.30
TLR9 Q9NR96 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5720269 0.85 DRD2 (0.39) ALDH1A1KDM4EDRD2DRD4TLR9
SCHEMBL5720197 0.84 CHRM1 (0.51) ALDH1A1CHRM1DRD2CHRM2CHRM3
SCHEMBL5720129 0.79 TLR9 (0.35) ALDH1A1DRD2DRD4TSHRRECQL
SCHEMBL5720167 0.74 TLR9 (0.35) CHRM1DRD2DRD4TLR9TLR7
SCHEMBL5478159 0.70 OPRM1 (0.57) CHRM1DRD2CHRM2CHRM3CHRM4
SCHEMBL5720110 0.69 TLR9 (0.40) ALDH1A1DRD2DRD4TSHRTLR9
SCHEMBL5720132 0.69 TRPV6 (0.41) ALDH1A1CHRM1KDM4EDRD2CHRM2
SCHEMBL5719999 0.68 CHRM2 (0.45) ALDH1A1DRD2CHRM2CHRM3DRD4
SCHEMBL5720092 0.68 CHRM1 (0.51) ALDH1A1CHRM1KDM4EDRD2CHRM2
SCHEMBL5476321 0.67 CHRM1 (0.71) CHRM1DRD2CHRM2CHRM3CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1515722-A4 OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION MERCK & CO INC (US) 2006-06-21 EP claimed
EP-1515722-A2 OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION Merck & Co., Inc. (US) 2005-03-23 EP claimed
WO-2003105781-A2 OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION MERCK & CO., INC. (US) 2003-12-24 WO claimed
EP-1515722-A4 OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION MERCK & CO INC (US) 2006-06-21 EP disclosed
EP-1515722-A2 OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION Merck & Co., Inc. (US) 2005-03-23 EP disclosed
WO-2003105781-A2 OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION MERCK & CO., INC. (US) 2003-12-24 WO disclosed