Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.60 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068451 | 0.83 | POLB (0.78) | LMNAKMT2AALDH1A1MEN1TSHR | |
| SCHEMBL10155593 | 0.83 | KMT2A (0.69) | LMNAKMT2AALDH1A1MEN1TP53 | |
| SCHEMBL4969968 | 0.80 | KMT2A (0.69) | KMT2AALDH1A1MEN1TP53POLB | |
| SCHEMBL29115758 | 0.79 | CYP2C9 (0.68) | LMNAKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL11511836 | 0.78 | ALDH1A1 (0.83) | LMNAKMT2AALDH1A1MAPK1TSHR | |
| SCHEMBL393581 | 0.78 | LMNA (0.59) | LMNAKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL9568839 | 0.78 | TGM2 (0.65) | LMNAKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL16705173 | 0.78 | KMT2A (0.71) | KMT2AALDH1A1TP53POLB | |
| SCHEMBL12049668 | 0.78 | KMT2A (0.71) | KMT2AALDH1A1 | |
| SCHEMBL4158719 | 0.77 | LMNA (0.58) | LMNAKMT2AALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673369-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | AstraZeneca AB (SE) | 2006-06-28 | — | — | EP | claimed |
| WO-2005030761-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-04-07 | — | — | WO | claimed |