Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 4/20 | 0.36 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.36 |
| ▸ | RHOC | P08134 | 1/20 | 0.35 |
| ▸ | RHOA | P61586 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5104439 | 0.95 | THRA (0.47) | THRATHRBLMNAALDH1A1MRGPRX4 | |
| SCHEMBL5119858 | 0.95 | LMNA (0.44) | THRATHRBLMNAALDH1A1MRGPRX4 | |
| SCHEMBL5722507 | 0.91 | THRA (0.38) | THRATHRBLMNAALDH1A1MRGPRX4 | |
| SCHEMBL5111277 | 0.87 | ALDH1A1 (0.46) | THRATHRBLMNAALDH1A1MRGPRX4 | |
| SCHEMBL4931364 | 0.87 | LMNA (0.44) | THRATHRBLMNAALDH1A1MRGPRX4 | |
| SCHEMBL5110472 | 0.87 | THRB (0.47) | THRATHRBLMNAALDH1A1MRGPRX4 | |
| SCHEMBL4934596 | 0.87 | THRA (0.47) | THRATHRBLMNAALDH1A1MRGPRX4 | |
| SCHEMBL4929444 | 0.86 | ALDH1A1 (0.46) | THRATHRBLMNAALDH1A1MRGPRX4 | |
| SCHEMBL4931997 | 0.86 | ALDH1A1 (0.46) | THRATHRBLMNAALDH1A1MRGPRX4 | |
| SCHEMBL5722805 | 0.85 | THRA (0.47) | THRATHRBLMNAMRGPRX4NR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732532-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092316-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |