Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | RHOC | P08134 | 1/20 | 0.38 |
| ▸ | RHOA | P61586 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4935433 | 0.92 | TRPA1 (0.43) | ALDH1A1LMNAMRGPRX4CYP3A4TACR1 | |
| SCHEMBL4931364 | 0.91 | LMNA (0.44) | ALDH1A1LMNAMRGPRX4TACR1ACP1 | |
| SCHEMBL5119858 | 0.91 | LMNA (0.44) | ALDH1A1LMNAMRGPRX4TACR1ACP1 | |
| SCHEMBL4931483 | 0.91 | TRPA1 (0.47) | ALDH1A1LMNAMRGPRX4CYP3A4TACR1 | |
| SCHEMBL5107813 | 0.90 | THRB (0.46) | ALDH1A1LMNAMRGPRX4TSHRRHOC | |
| SCHEMBL5110472 | 0.89 | THRB (0.47) | ALDH1A1LMNAMRGPRX4TACR1ACP1 | |
| SCHEMBL4931997 | 0.89 | ALDH1A1 (0.46) | ALDH1A1LMNAMRGPRX4TACR1ACP1 | |
| SCHEMBL5110736 | 0.89 | ALDH1A1 (0.46) | ALDH1A1LMNAMRGPRX4TACR1ACP1 | |
| SCHEMBL5116030 | 0.89 | THRA (0.49) | ALDH1A1LMNAMRGPRX4THRATHRB | |
| SCHEMBL4929409 | 0.88 | ALDH1A1 (0.43) | ALDH1A1LMNAMRGPRX4TACR1ACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004251-A1 | Novel Pharmaceutical Compositions Comprising Agonists of the Thyroid Receptor | KARO BIO AB (SE) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004251-A1 | Novel Pharmaceutical Compositions Comprising Agonists of the Thyroid Receptor | TSHR, TRHR, THRA | ALDH1A1 2530/4885LMNA 3643/4885MRGPRX4 116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.