Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28872280 | 0.84 | HIF1A (0.54) | MTNR1AMTNR1BHIF1AALDH1A1ROCK2 | |
| SCHEMBL28872227 | 0.82 | HIF1A (0.49) | MTNR1AMTNR1BHIF1AALDH1A1ROCK2 | |
| SCHEMBL14031174 | 0.80 | PTPN1 (0.61) | MTNR1AMTNR1BPTPN1 | |
| SCHEMBL885000 | 0.80 | MTNR1A (0.71) | MTNR1AMTNR1BNPSR1ALDH1A1 | |
| SCHEMBL7495080 | 0.80 | ROCK2 (0.59) | MTNR1AMTNR1BHIF1ANPSR1ALDH1A1 | |
| SCHEMBL11857049 | 0.77 | MAPT (0.45) | MTNR1AMTNR1BALDH1A1PTPN1 | |
| SCHEMBL13345684 | 0.77 | HSD17B10 (0.51) | HIF1AALDH1A1PTPN1 | |
| SCHEMBL4658256 | 0.76 | HIF1A (0.43) | MTNR1AMTNR1BHIF1ANPSR1ALDH1A1 | |
| SCHEMBL16950132 | 0.76 | HIF1A (0.49) | HIF1AALDH1A1ROCK2 | |
| SCHEMBL23774185 | 0.76 | MTNR1A (0.49) | MTNR1AMTNR1BNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633715-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | Pfizer Limited (GB) | 2006-03-15 | — | — | EP | claimed |
| WO-2004108676-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | PFIZER LIMITED (GB) | 2004-12-16 | — | — | WO | claimed |
| EP-1633715-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | Pfizer Limited (GB) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004108676-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | PFIZER LIMITED (GB) | 2004-12-16 | — | — | WO | disclosed |