Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL940131 | 0.87 | ALDH1A1 (0.60) | SIRT2KMT2AALDH1A1ADRB2KDM4E | |
| Hydrochloric Acid SCHEMBL28193722 | 0.86 | ALDH1A1 (0.58) | SIRT2KMT2AALDH1A1ADRB2KDM4E | |
| SCHEMBL4735612 | 0.85 | ALDH1A1 (0.54) | SIRT2KMT2AALDH1A1ADRB2KDM4E | |
| SCHEMBL11782261 | 0.85 | SIRT2 (0.48) | SIRT2KMT2AALDH1A1ADRB2KDM4E | |
| SCHEMBL21357052 | 0.85 | ALDH1A1 (0.61) | SIRT2KMT2AALDH1A1ADRB2KDM4E | |
| SCHEMBL5723934 | 0.84 | KEAP1 (0.56) | CYP19A1ESR1ESR2KMT2AALDH1A1 | |
| SCHEMBL5724287 | 0.82 | DRD2 (0.50) | SIRT2KMT2AALDH1A1ADRB2SLC6A5 | |
| SCHEMBL4354269 | 0.81 | KDR (0.56) | SIRT2KMT2AALDH1A1ADRB2KDM4E | |
| SCHEMBL29817950 | 0.81 | KMT2A (0.50) | KMT2AALDH1A1CA2SLC6A5PARP1 | |
| SCHEMBL29246624 | 0.80 | SIRT2 (0.43) | SIRT2KMT2AALDH1A1ADRB2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633715-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | Pfizer Limited (GB) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004108676-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | PFIZER LIMITED (GB) | 2004-12-16 | — | — | WO | disclosed |