SCHEMBL5724312

SCHEMBL5724312

CC(=O)SC1CN(c2nc(C(=O)N3CC(O[Si](c4ccccc4)(c4ccccc4)C(C)(C)C)C3)co2)C1

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SCD O00767 2/20 0.32
SCD5 Q86SK9 2/20 0.32
RIPK1 Q13546 1/20 0.31
RBP4 P02753 3/20 0.31
HCRTR1 O43613 1/20 0.31
HCRTR2 O43614 1/20 0.31
TP53 P04637 1/20 0.30
EIF4A3 P38919 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5724090 0.88 SCD (0.34) SCDSCD5RIPK1RBP4HCRTR1
SCHEMBL5724174 0.87 RIPK1 (0.41) SCDSCD5RIPK1RBP4HCRTR1
SCHEMBL5724367 0.84 DGAT2 (0.35) SCD5RIPK1RBP4HCRTR1HCRTR2
SCHEMBL5724188 0.84 SCD (0.32) SCDSCD5RIPK1RBP4HCRTR1
SCHEMBL5724344 0.83 HTR2C (0.37) SCDSCD5TP53
SCHEMBL5724981 0.82 TTR (0.35) RBP4HCRTR1HCRTR2
SCHEMBL5723594 0.81 RIPK1 (0.37) SCD5RIPK1HCRTR1HCRTR2
SCHEMBL5723733 0.80 ALDH1A1 (0.39)
SCHEMBL5724415 0.79 DAGLA (0.36) RBP4HCRTR1HCRTR2
SCHEMBL5724473 0.78 FGFR1 (0.34) RIPK1RBP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1340757-B1 1-METHYLCARBAPENEM DERIVATIVES SANKYO CO (JP) 2006-10-11 EP disclosed
US-7001897-B2 1-methylcarbapenem derivatives SANKYO COMPANY, LIMITED (JP) 2006-02-21 US disclosed
US-20040014962-A1 1-Methylcarbapenem derivatives SANKYO COMPANY, LIMITED (JP) 2004-01-22 US disclosed
EP-1340757-A1 1-METHYLCARBAPENEM DERIVATIVES Sankyo Company, Limited (JP) 2003-09-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040014962-A1 1-Methylcarbapenem derivatives CD14, CPT1A, ACMSD SCD 54/4885SCD5 95/4885RIPK1 2287/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.