Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 10/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5446847 | 0.88 | TSHR (0.73) | TSHRGAAL3MBTL1SMN1; SMN2TDP1 | |
| SCHEMBL13977766 | 0.86 | GAA (0.68) | TSHRGAAL3MBTL1SMN1; SMN2HTT | |
| SCHEMBL7821728 | 0.84 | TSHR (0.77) | TSHRGAAL3MBTL1SMN1; SMN2TDP1 | |
| SCHEMBL15619393 | 0.82 | PTGS2 (0.54) | TSHRGAAL3MBTL1SMN1; SMN2HTT | |
| SCHEMBL8585196 | 0.77 | ALDH1A1 (0.53) | TSHRGAAL3MBTL1SMN1; SMN2HTT | |
| SCHEMBL11815924 | 0.76 | POLB (0.60) | TSHRGAAL3MBTL1SMN1; SMN2HTT | |
| SCHEMBL11811386 | 0.76 | TSHR (0.56) | TSHRGAAL3MBTL1SMN1; SMN2TDP1 | |
| SCHEMBL14157352 | 0.74 | CA1 (0.62) | TSHRGAASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL381076 | 0.74 | POLB (0.53) | TSHRGAAL3MBTL1SMN1; SMN2TDP1 | |
| SCHEMBL27158903 | 0.73 | L3MBTL1 (0.67) | TSHRGAAL3MBTL1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638540-A2 | PYRAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS PLATELET AGGREGATION INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005002574-A1 | PYRAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS PLATELET AGGREGATION INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2005-01-13 | — | — | WO | disclosed |
| WO-2005000281-A2 | PYRAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS PLATELET AGGREGATION INHIBITORS | ACTELION PHARMACEUTICALS LTD. (CH) | 2005-01-06 | — | — | WO | disclosed |