Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28742962 | 0.81 | ALDH1A1 (0.44) | KDM4EHSD17B10HPGDRAB9ANPC1 | |
| SCHEMBL11808741 | 0.79 | RAB9A (0.42) | KDM4EHSD17B10HPGDRAB9ANPC1 | |
| SCHEMBL765304 | 0.79 | KDM4E (0.44) | KDM4EHSD17B10HPGDNPC1KMT2A | |
| SCHEMBL18097396 | 0.79 | KMT2A (0.45) | HSD17B10HPGDRAB9ANPC1KMT2A | |
| SCHEMBL7079234 | 0.76 | KMT2A (0.40) | HSD17B10RAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL4607918 | 0.74 | KDM4E (0.36) | KDM4EHSD17B10HPGDRAB9ANPC1 | |
| SCHEMBL5728011 | 0.74 | KDM4E (0.44) | KDM4EHSD17B10HPGDKMT2AALDH1A1 | |
| SCHEMBL5154245 | 0.73 | — | — | |
| SCHEMBL5728136 | 0.73 | KDM4E (0.50) | KDM4EHSD17B10HPGDKMT2AALDH1A1 | |
| SCHEMBL11351584 | 0.73 | KDM4E (0.39) | KDM4EHSD17B10HPGDKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694665-A2 | SUBSTITUTED THIOPHENES | AiCuris GmbH & Co. KG (DE) | 2006-08-30 | — | — | EP | disclosed |
| WO-2006072348-A2 | ALKINYL-SUBSTITUTED THIOPHENES | AICURIS GMBH & CO. KG (DE) | 2006-07-13 | — | — | WO | disclosed |
| WO-2005063734-A2 | SUBSTITUTED THIOPHENES | AICURIS GMBH & CO. KG (DE) | 2005-07-14 | — | — | WO | disclosed |
| WO-1997028166-A1 | THIENOQUINOLINES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1997-08-07 | — | — | WO | disclosed |