Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 14/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 14/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5721981 | 0.88 | CDC7 (0.43) | CDC7DBF4PTGS2RARARARB | |
| SCHEMBL27607456 | 0.84 | RARA (0.40) | CDC7DBF4PTGS2RARARARB | |
| SCHEMBL5750632 | 0.82 | LMNA (0.43) | IDO1 | |
| SCHEMBL27607507 | 0.80 | RARA (0.41) | CDC7DBF4PTGS2RARARARB | |
| SCHEMBL28750823 | 0.75 | LMNA (0.33) | — | |
| SCHEMBL5731004 | 0.74 | PTPN1 (0.41) | MAPK14 | |
| SCHEMBL28428668 | 0.70 | MEN1 (0.42) | CDC7DBF4MAPK14 | |
| SCHEMBL21834496 | 0.69 | CYP1A2 (0.44) | PTGS2 | |
| SCHEMBL3813607 | 0.69 | PTGS2 (0.47) | MAPK14PTGS2 | |
| SCHEMBL6986435 | 0.69 | TARBP2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401434-B1 | MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS (PPAR) | LILLY CO ELI (US) | 2006-11-15 | — | — | EP | disclosed |
| CN-1578659-A | Modulators of peroxisome proliferator activated receptors (ppar) | LILLY CO ELI (US) | 2005-02-09 | — | — | CN | disclosed |
| EP-1401434-A1 | MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS (PPAR) | ELI LILLY AND COMPANY (US) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002100403-A1 | MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS (PPAR) | ELI LILLY AND COMPANY (US) | 2002-12-19 | — | — | WO | disclosed |