Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.40 |
| ▸ | WNT3A | P56704 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5729107 | 0.89 | NR1H2 (0.38) | NR1H2NR1H3GPR119USP30ALDH1A1 | |
| SCHEMBL5729368 | 0.89 | GPR119 (0.43) | NR1H2NR1H3GPR119USP30ALDH1A1 | |
| SCHEMBL6799065 | 0.78 | GPR119 (0.45) | GPR119USP30ALDH1A1 | |
| SCHEMBL5731177 | 0.75 | F10 (0.49) | — | |
| SCHEMBL10320809 | 0.74 | WNT3A (0.56) | GPR119WNT3AALDH1A1MEN1MAPT | |
| SCHEMBL16691325 | 0.73 | CKS1B (0.52) | GPR119 | |
| SCHEMBL18502950 | 0.71 | WNT3A (0.44) | NR1H2GPR119WNT3AALDH1A1MEN1 | |
| SCHEMBL20510655 | 0.71 | GPR119 (0.46) | NR1H2GPR119WNT3A | |
| SCHEMBL31741180 | 0.68 | TBK1 (0.46) | NR1H2NR1H3GPR119USP30WNT3A | |
| SCHEMBL641072 | 0.68 | ALDH1A1 (0.53) | GPR119USP30WNT3AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1188755-B1 | ACYLHYDRAZINE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-1188755-A1 | ACYLHYDRAZINE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-03-20 | — | — | EP | disclosed |