Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | GFER | P55789 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5731969 | 0.77 | KMT2A (0.67) | KMT2ALMNAGFERMAPTSLC6A2 | |
| SCHEMBL2493368 | 0.77 | KMT2A (0.67) | KMT2ALMNAGFERMAPTCYP2D6 | |
| SCHEMBL953078 | 0.77 | NISCH (0.54) | LMNAMAPTCYP2D6CYP1A2NISCH | |
| Hydrochloric Acid SCHEMBL2493369 | 0.76 | KMT2A (0.69) | KMT2ALMNAGFERMAPTCYP2D6 | |
| SCHEMBL5732043 | 0.75 | KMT2A (0.67) | KMT2ALMNAGFERMAPTCYP2D6 | |
| SCHEMBL5733176 | 0.75 | KMT2A (0.97) | KMT2ALMNAGFERMAPTCYP2D6 | |
| SCHEMBL5731047 | 0.75 | KMT2A (0.67) | KMT2ALMNAGFERMAPTCYP2D6 | |
| SCHEMBL561423 | 0.74 | LMNA (0.56) | LMNASLC6A2SLC6A4CYP2D6SMN1; SMN2 | |
| Bromide SCHEMBL3176423 | 0.73 | KMT2A (0.65) | KMT2ALMNAGFERMAPTCYP2D6 | |
| SCHEMBL19061731 | 0.73 | POLB (0.40) | KMT2ASLC6A2HTR1ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-A1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | Aventis Pharmaceuticals, Inc. (US) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005014555-A1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-02-17 | — | — | WO | disclosed |