Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 6/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19062036 | 0.87 | POLB (0.44) | POLBMAPK1CHRNB2CHRNA4DRD2 | |
| SCHEMBL19061730 | 0.86 | KDM4E (0.41) | POLBMAPK1CHRNB2CHRNA4HSD17B10 | |
| SCHEMBL19061892 | 0.85 | MMP1 (0.43) | MAPK1CHRNB2CHRNA4HSD17B10PKM | |
| SCHEMBL19061593 | 0.85 | ALDH1A1 (0.46) | POLBMAPK1CHRNB2CHRNA4HSD17B10 | |
| SCHEMBL19061889 | 0.83 | PKM (0.46) | POLBMAPK1CHRNB2CHRNA4HSD17B10 | |
| SCHEMBL19061452 | 0.83 | PKM (0.48) | POLBMAPK1CHRNB2CHRNA4DRD2 | |
| SCHEMBL19061884 | 0.83 | KMT2A (0.49) | POLBMAPK1CHRNB2CHRNA4DRD2 | |
| SCHEMBL19019922 | 0.82 | MAPK1 (0.50) | POLBMAPK1CHRNB2CHRNA4HSD17B10 | |
| SCHEMBL19019870 | 0.80 | CHRNB2 (0.43) | POLBMAPK1CHRNB2CHRNA4HSD17B10 | |
| SCHEMBL19062035 | 0.80 | HSD17B10 (0.40) | POLBMAPK1CHRNB2CHRNA4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184514-A1 | AUTOPHAGY INHIBITORS | Deutsches Krebsforschungszentrum (DE) | 2017-06-28 | — | — | EP | disclosed |