Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2379469 | 0.78 | HIF1A (0.39) | HIF1AALDH1A1ROCK2PTPN1HTR2A | |
| SCHEMBL4658256 | 0.78 | HIF1A (0.43) | HIF1AALDH1A1ROCK2PTPN1HTR2A | |
| SCHEMBL2380020 | 0.77 | ALDH1A1 (0.39) | HIF1AALDH1A1ROCK2PTPN1HTR2A | |
| SCHEMBL6703863 | 0.76 | HIF1A (0.46) | HIF1AALDH1A1ROCK2PTPN1HDAC3 | |
| SCHEMBL2781208 | 0.76 | ROCK2 (0.41) | HIF1AALDH1A1ROCK2HPGDTP53 | |
| SCHEMBL2782719 | 0.73 | KMT2A (0.49) | MAPTLMNAKMT2ASMN1; SMN2 | |
| SCHEMBL2380133 | 0.73 | ROCK2 (0.41) | HIF1AALDH1A1ROCK2PTPN1HTR2A | |
| SCHEMBL2780656 | 0.73 | NPC1 (0.52) | ALDH1A1TP53MAPTKDM4ELMNA | |
| SCHEMBL5723907 | 0.73 | MTNR1A (0.56) | HIF1AALDH1A1ROCK2PTPN1 | |
| SCHEMBL2779634 | 0.72 | RXFP1 (0.40) | HIF1AALDH1A1ROCK2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716127-A2 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | Abbott GmbH & Co. KG (DE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005082871-A2 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBOTT GMBH & CO. KG (DE) | 2005-09-09 | — | — | WO | disclosed |