Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | ALDH1A2 | O94788 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739101 | 0.85 | RAB9A (0.52) | ALDH1A3PDE10AALDH1A2NPC1RAB9A | |
| SCHEMBL24307129 | 0.78 | ALDH1A3 (0.68) | ALDH1A3PDE10AALDH1A2NPC1RAB9A | |
| SCHEMBL5737921 | 0.76 | ALDH1A3 (0.72) | ALDH1A3PDE10AALDH1A2NPC1RAB9A | |
| SCHEMBL5738164 | 0.75 | ALDH1A3 (0.51) | ALDH1A3PDE10AALDH1A2NPC1RAB9A | |
| SCHEMBL5737718 | 0.74 | CASP3 (0.64) | ALDH1A3PDE10AALDH1A2NPC1RAB9A | |
| SCHEMBL31367566 | 0.73 | ALDH1A3 (0.58) | ALDH1A3ALDH1A2IDO1GRM5XDH | |
| SCHEMBL27082490 | 0.72 | PDE10A (0.51) | ALDH1A3PDE10AALDH1A2NPC1RAB9A | |
| SCHEMBL3817089 | 0.72 | TP53 (0.65) | ALDH1A3NPC1RAB9AALDH1A1PKM | |
| SCHEMBL5738406 | 0.72 | ALDH1A1 (0.72) | ALDH1A3PDE10AALDH1A2NPC1RAB9A | |
| SCHEMBL5739105 | 0.72 | RAB9A (0.68) | ALDH1A3PDE10AALDH1A2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401836-B1 | IMIDAZO¬1,2-A|PYRIDINE DERIVATIVES FOR THE PROPHYLAXIS AND TREATMENT OF HERPES VIRAL INFECTIONS | SMITHKLINE BEECHAM CORP (US) | 2006-08-23 | — | — | EP | disclosed |
| US-20060167252-A1 | Imidazo[1,2-a]pyridine derivatives for treatment of herpes viral infections | GUDMUNDSSON KRISTJAN | 2006-07-27 | — | — | US | disclosed |
| US-20050228004-A1 | Imidazo'1,2-a!pyridine derivatives for the prophylaxis and treatment of herpes viral infections | SMITHKLINE BEECHAM CORPORATION | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228004-A1 | Imidazo'1,2-a!pyridine derivatives for the prophylaxis and treatment of herpes viral infections | TPMT, IRF3, ZC3HAV1 | ALDH1A3 1186/4885PDE10A 1998/4885ALDH1A2 1345/4885 |
| US-20060167252-A1 | Imidazo[1,2-a]pyridine derivatives for treatment of herpes viral infections | IRF3, IFNAR1, IL2 | ALDH1A3 1244/4885PDE10A 2049/4885ALDH1A2 1095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.