Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 14/20 | 0.67 |
| ▸ | CA2 | P00918 | 14/20 | 0.67 |
| ▸ | CA9 | Q16790 | 6/20 | 0.67 |
| ▸ | CA12 | O43570 | 4/20 | 0.67 |
| ▸ | CA4 | P22748 | 1/20 | 0.67 |
| ▸ | CA6 | P23280 | 1/20 | 0.67 |
| ▸ | CA5A | P35218 | 1/20 | 0.67 |
| ▸ | CA7 | P43166 | 1/20 | 0.67 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.67 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225275 | 0.89 | CES1 (0.66) | CA1CA2CA9CA12CA4 | |
| SCHEMBL10692669 | 0.86 | MAPT (0.57) | CA1CA2CA9CA12CA4 | |
| SCHEMBL10693412 | 0.86 | KMT2A (0.60) | CA1CA2CA9CA12CA4 | |
| SCHEMBL5737935 | 0.84 | MAPT (0.62) | CA1CA2CA9CA12CA4 | |
| SCHEMBL5737038 | 0.82 | PGR (0.63) | MAPTMEN1LMNAPKMKMT2A | |
| SCHEMBL248783 | 0.81 | CA1 (1.00) | CA1CA2CA9CA12CA4 | |
| SCHEMBL29906360 | 0.81 | CA1 (1.00) | CA1CA2CA9CA12CA4 | |
| SCHEMBL23109373 | 0.81 | PKM (0.62) | MAPTNPSR1MEN1LMNAPKM | |
| SCHEMBL11085201 | 0.79 | PRMT1 (0.60) | CA1CA2CA9HTTMAPT | |
| SCHEMBL5737651 | 0.79 | ALDH1A1 (0.62) | HTTMAPTNPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064274-B1 | BENZENESULFONAMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |
| US-6667342-B1 | Elevation of pyruvate dehydrogenase activity | ASTRAZENECA AB (SE) | 2003-12-23 | — | — | US | disclosed |
| EP-1064274-A1 | BENZENESULFONAMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | AstraZeneca AB (SE) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999047508-A1 | BENZENESULFONAMIDE-DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 1999-09-23 | — | — | WO | disclosed |