Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL23497511 | 0.81 | CACNA1H (0.36) | NPC1GAARAB9AALDH1A1CACNA1H | |
| SCHEMBL5738314 | 0.79 | PSMB8 (0.51) | NPC1GAARAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL7045259 | 0.76 | NUDT1 (0.60) | NPC1GAARAB9AALDH1A1MEN1 | |
| SCHEMBL1625967 | 0.75 | NPC1 (0.53) | NPC1GAARAB9AALDH1A1MEN1 | |
| SCHEMBL7608556 | 0.74 | GPR84 (0.41) | ALDH1A1MEN1MAPTKMT2AKDM4E | |
| SCHEMBL3421747 | 0.72 | HTT (0.52) | NPC1GAARAB9AALDH1A1MEN1 | |
| SCHEMBL12309204 | 0.71 | EGLN1 (0.42) | CACNA1H | |
| SCHEMBL5738714 | 0.71 | CBFB (0.45) | NPC1GAARAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL7231111 | 0.71 | NPC1 (0.43) | NPC1GAARAB9AALDH1A1MEN1 | |
| SCHEMBL5738369 | 0.71 | CACNA1H (0.36) | GAACACNA1HPNMTTDP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1176959-B1 | NOVEL PROLINES AS ANTIMICROBIAL AGENTS | MERCK & CO INC (US) | 2006-03-08 | — | — | EP | disclosed |
| US-6579894-B2 | Bactericides, fungicides | MERCK & CO., INC. | 2003-06-17 | — | — | US | disclosed |
| US-20030013724-A1 | Novel prolines as antimicrobial agents | HAMMOND MILTON L (US) | 2003-01-16 | — | — | US | disclosed |
| EP-1176959-A4 | NOVEL PROLINES AS ANTIMICROBIAL AGENTS | MERCK & CO INC (US) | 2002-10-09 | — | — | EP | disclosed |
| US-6417217-B1 | TREATING INFECTIONS WITH HETEROCYCLIC MICROBIOCIDES THIS INVENTION RELATES TO THE FIELD OF TRANSFER RIBONUCLEIC ACID (TRNA) SYNTHETASE INHIBITORS, THEIR PREPARATION AND THEIR USE AS ANTIMICROBIAL ADMINISTERING TO THE SUBJECT A | MERCK & CO., INC. | 2002-07-09 | — | — | US | disclosed |
| EP-1176959-A1 | NOVEL PROLINES AS ANTIMICROBIAL AGENTS | Merck & Co., Inc. (US) | 2002-02-06 | — | — | EP | disclosed |
| US-6333344-B1 | ENZYME INHIBITORS AND BACTERICIDES | MERCK & CO. | 2001-12-25 | — | — | US | disclosed |
| WO-2000066119-A1 | NOVEL PROLINES AS ANTIMICROBIAL AGENTS | MERCK & CO., INC. (US) | 2000-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013724-A1 | Novel prolines as antimicrobial agents | AARS1, EPRS1, TRMT1 | NPC1 1838/4885GAA 1631/4885RAB9A 2175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.