Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.43 |
| ▸ | PTGES | O14684 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14886010 | 0.89 | ALOX5 (0.44) | CA2KDM4EALDH1A1HPGDUSP2 | |
| SCHEMBL14879711 | 0.89 | ALOX5 (0.44) | CA2KDM4EALDH1A1HPGDUSP2 | |
| SCHEMBL16581177 | 0.84 | ALDH1A1 (0.40) | CA2KDM4EALDH1A1HPGDUSP2 | |
| SCHEMBL2741938 | 0.83 | CA2 (0.42) | CA2KDM4EALDH1A1HPGDUSP2 | |
| SCHEMBL14885916 | 0.82 | HCAR3 (0.41) | CA2ALDH1A1LMNAALOX5PTGES | |
| SCHEMBL10224398 | 0.82 | KMT2A (0.43) | KDM4EALDH1A1HPGDUSP2LMNA | |
| SCHEMBL574554 | 0.82 | CISD1 (0.43) | CA2KDM4EALDH1A1HPGDUSP2 | |
| SCHEMBL2741926 | 0.82 | CA2 (0.42) | CA2KDM4EALDH1A1HPGDUSP2 | |
| SCHEMBL2741940 | 0.81 | CA2 (0.46) | CA2KDM4EALDH1A1HPGDUSP2 | |
| SCHEMBL229433 | 0.81 | LMNA (0.64) | CA2KDM4EALDH1A1HPGDUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598478-A2 | ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | Neurotherapeutics Pharma, Inc. (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012018635-A2 | ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | NEUROTHERAPEUTICS PHARMA, INC. (US) | 2012-02-09 | — | — | WO | disclosed |