Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29515045 | 0.78 | SMN1; SMN2 (0.45) | ALDH1A1 | |
| SCHEMBL18489377 | 0.78 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL24322112 | 0.78 | SMN1; SMN2 (0.45) | ALDH1A1 | |
| SCHEMBL18489379 | 0.78 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL3228504 | 0.76 | APLNR (0.39) | ALDH1A1 | |
| SCHEMBL30328009 | 0.74 | TRPV4 (0.40) | PTGS1PTGS2 | |
| SCHEMBL2604908 | 0.74 | ESR1 (0.42) | ESR1ESR2 | |
| SCHEMBL20023726 | 0.72 | NQO1 (0.48) | ALDH1A1 | |
| SCHEMBL16647732 | 0.72 | MBOAT4 (0.42) | ESR1ESR2HDAC6 | |
| SCHEMBL16935021 | 0.72 | ALDH1A1 (0.31) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622898-A1 | PROCESSES FOR MAKING THIAZOLIDINEDIONE DERIVATIVES AND COMPOUNDS THEREOF | Synthon B.V. (NL) | 2006-02-08 | — | — | EP | disclosed |
| US-20050059708-A1 | Processes for making thiazolidinedione derivatives and compounds thereof | SYNTHON BV (NL) | 2005-03-17 | — | — | US | disclosed |
| WO-2004101560-A1 | PROCESSES FOR MAKING THIAZOLIDINEDIONE DERIVATIVES AND COMPOUNDS THEREOF | SYNTHON B.V. (NL) | 2004-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059708-A1 | Processes for making thiazolidinedione derivatives and compounds thereof | PPARD, PPARG, PPARA | PTGS1 1531/4885PTGS2 1859/4885ESR1 1266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.