Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.67 |
| ▸ | MMP13 | P45452 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.58 |
| ▸ | PRKACA | P17612 | 2/20 | 0.58 |
| ▸ | PRKX | P51817 | 2/20 | 0.58 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | GSK3A | P49840 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.58 |
| ▸ | GRK5 | P34947 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KDM1A | O60341 | 3/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5209384 | 0.80 | MMP13 (0.72) | AURKAMMP13LMNAHPGDROCK1 | |
| SCHEMBL5332068 | 0.80 | MMP13 (1.00) | AURKAMMP13LMNAHPGDROCK1 | |
| SCHEMBL31061610 | 0.80 | MMP13 (1.00) | AURKAMMP13LMNAHPGDROCK1 | |
| SCHEMBL9416645 | 0.80 | MMP13 (0.94) | AURKAMMP13LMNAHPGDROCK1 | |
| SCHEMBL14082327 | 0.79 | ROCK1 (0.69) | AURKAMMP13LMNAHPGDROCK1 | |
| SCHEMBL3037037 | 0.79 | MMP13 (0.78) | AURKAMMP13LMNAHPGDROCK1 | |
| SCHEMBL5332057 | 0.79 | MMP13 (0.82) | AURKAMMP13LMNAHPGDROCK1 | |
| SCHEMBL1568252 | 0.78 | ROCK2 (0.86) | AURKAMMP13LMNAHPGDROCK1 | |
| SCHEMBL3820733 | 0.77 | ROCK2 (0.76) | AURKAMMP13LMNAHPGDROCK1 | |
| SCHEMBL1767576 | 0.77 | MMP13 (0.67) | AURKAMMP13LMNAHPGDROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678149-A2 | 4-AMINO(AZA)QUINOLINE DERIVATIVES AS CAPSAICIN RECEPTOR AGONISTS | NEUROGEN CORPORATION (US) | 2006-07-12 | — | — | EP | claimed |
| WO-2005042498-A2 | 4-AMINO (AZA) QUINOLINE DERIVATIVES AS CAPSAICIN RECEPTOR AGONISTS | NEUROGEN CORPORATION (US) | 2005-05-12 | — | — | WO | claimed |
| US-20060194805-A1 | Capsaicin receptor agonists | NEUROGEN CORPORATION (US) | 2006-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194805-A1 | Capsaicin receptor agonists | TRPV1, HCAR1, CNR1 | AURKA 4834/4885MMP13 3450/4885LMNA 2830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.