Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.57 |
| ▸ | DOT1L | Q8TEK3 | 4/20 | 0.55 |
| ▸ | TERT | O14746 | 5/20 | 0.54 |
| ▸ | AGPAT2 | O15120 | 3/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741860 | 0.89 | MAPT (0.52) | HSP90AA1AGPAT2HSP90AB1CYP1A2CYP2D6 | |
| SCHEMBL5740482 | 0.85 | ALOX15 (0.48) | HSP90AA1AGPAT2HSP90AB1CYP1A2CYP2D6 | |
| SCHEMBL5742562 | 0.85 | MAPT (0.53) | HSP90AA1AGPAT2HSP90AB1RAB9A | |
| SCHEMBL5741412 | 0.85 | DOT1L (0.57) | DOT1LTERTAGPAT2OPRL1CYP1A2 | |
| SCHEMBL5740342 | 0.85 | AGPAT2 (0.59) | HSP90AA1AGPAT2HSP90AB1 | |
| SCHEMBL5744362 | 0.84 | AGPAT2 (0.46) | HSP90AA1AGPAT2HSP90AB1 | |
| SCHEMBL5741832 | 0.83 | AGPAT2 (0.46) | HSP90AA1AGPAT2HSP90AB1CYP1A2CYP2D6 | |
| SCHEMBL5743121 | 0.83 | AGPAT2 (0.55) | HSP90AA1AGPAT2HSP90AB1 | |
| SCHEMBL5741580 | 0.82 | ACP1 (0.48) | HSP90AA1AGPAT2HSP90AB1CYP1A2CYP2D6 | |
| SCHEMBL5741949 | 0.81 | TP53 (0.49) | HSP90AA1AGPAT2HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339706-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |