Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 6/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3540730 | 0.85 | HTR1A (0.47) | HTR1AHTR3AITGB2ICAM1ITGAL | |
| SCHEMBL5735133 | 0.82 | APP (0.45) | APPL3MBTL1OPRD1OPRK1PSEN1 | |
| SCHEMBL4699736 | 0.75 | HTR1A (0.57) | HTR1AHTR3AITGB2ICAM1ITGAL | |
| SCHEMBL3539669 | 0.75 | HTR1A (0.39) | HTR1AHTR3APSEN1PSEN2APH1B | |
| SCHEMBL5741855 | 0.75 | L3MBTL1 (0.44) | HTR1AHTR3AAPPL3MBTL1OPRD1 | |
| SCHEMBL3544412 | 0.74 | MEN1 (0.42) | HTR1AHTR3AITGB2ICAM1ITGAL | |
| SCHEMBL5743102 | 0.72 | L3MBTL1 (0.41) | HTR1AAPPL3MBTL1OPRD1OPRK1 | |
| SCHEMBL3542345 | 0.71 | ALDH1A1 (0.45) | HTR1AHTR3AAPPALDH1A1LMNA | |
| SCHEMBL5744778 | 0.71 | L3MBTL1 (0.44) | HTR1AHTR3AL3MBTL1OPRD1OPRK1 | |
| SCHEMBL6608659 | 0.71 | SCN5A (0.52) | HTR1AAPPL3MBTL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626720-A1 | 4-(2-PHENYLSULFANYL-PHENYL)-PIPERIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. Lundbeck A/S (DK) | 2006-02-22 | — | — | EP | disclosed |
| WO-2004087156-A1 | 4-(2-PHENYLSULFANYL-PHENYL)-PIPERIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2004-10-14 | — | — | WO | disclosed |