Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.46 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5248649 | 0.91 | KIF11 (0.45) | KIF11KIF23TLR7SIGMAR1FNTA | |
| SCHEMBL5246048 | 0.84 | KIF11 (0.44) | KIF11TLR7DRD2SIGMAR1FNTA | |
| SCHEMBL3871323 | 0.81 | KIF11 (0.49) | KIF11KIF23TLR7SIGMAR1BRD4 | |
| SCHEMBL5740661 | 0.81 | TLR7 (0.43) | KIF11KIF23TLR7SIGMAR1BRD4 | |
| SCHEMBL3863849 | 0.80 | KIF11 (0.49) | KIF11KIF23TLR7SIGMAR1FNTA | |
| SCHEMBL4039832 | 0.79 | KIF11 (0.48) | KIF11KIF23TLR7AKT1BRD4 | |
| SCHEMBL5246236 | 0.79 | KIF11 (0.52) | KIF11KIF23TLR7SIGMAR1 | |
| SCHEMBL4750947 | 0.79 | KIF11 (0.45) | KIF11TLR7 | |
| SCHEMBL5740939 | 0.79 | KIF11 (0.47) | KIF11KIF23TLR7SIGMAR1 | |
| SCHEMBL3863579 | 0.79 | KIF11 (0.75) | KIF11KIF23 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628981-A2 | BICYCLICPYRIMIDONES AND THEIR USE TO TREAT DISEASES | Bristol-Myers Squibb Company (US) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004106492-A2 | BICYCLICPYRIMIDONES AND THEIR USE TO TREAT DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-09 | — | — | WO | disclosed |