Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 9/20 | 0.38 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011216 | 0.75 | PNMT (0.44) | TSHRPNMT | |
| SCHEMBL9207161 | 0.72 | TSHR (0.53) | TSHRNPSR1MAPKAPK2GRIA2 | |
| Hydrochloric Acid SCHEMBL10489402 | 0.71 | TSHR (0.55) | TSHRNPSR1MAPKAPK2GRIA2 | |
| SCHEMBL19642816 | 0.70 | SIRT1 (0.41) | TSHR | |
| SCHEMBL19643822 | 0.70 | SIRT1 (0.41) | TSHR | |
| SCHEMBL25373658 | 0.69 | TSHR (0.60) | TSHRNPSR1 | |
| SCHEMBL30561807 | 0.69 | TSHR (0.60) | TSHRNPSR1 | |
| SCHEMBL28143019 | 0.67 | DRD2 (0.59) | TSHRNPSR1 | |
| SCHEMBL9210495 | 0.67 | PNMT (0.37) | TSHRPNMT | |
| SCHEMBL12192723 | 0.66 | MAOA (0.50) | TSHRNPSR1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723148-A2 | THIENO-IMINO ACID DERIVATIVES FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS | Sanofi-Aventis Deutschland GmbH (DE) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005073236-A2 | THIENO-IMINO ACID DERIVATIVES FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-08-11 | — | — | WO | disclosed |