Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.50 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5743990 | 0.86 | DHFR (0.53) | HRH4HRH3DHFRLMNAMAPT | |
| Hydrochloric Acid SCHEMBL5743802 | 0.84 | DHFR (0.52) | HRH4HRH3DHFRLMNAMAPT | |
| SCHEMBL5740772 | 0.83 | SMN1; SMN2 (0.53) | HRH4HRH3LMNAMAPTHTT | |
| SCHEMBL5741120 | 0.80 | HRH4 (0.59) | HRH4HRH3DHFRLMNAMAPT | |
| SCHEMBL5743624 | 0.78 | SMPD3 (0.53) | HRH4HRH3DHFR | |
| SCHEMBL5742735 | 0.72 | MAPT (0.64) | HRH4HRH3DHFRLMNAMAPT | |
| SCHEMBL10678810 | 0.71 | HRH4 (0.70) | HRH4HRH3LMNAHTTSMN1; SMN2 | |
| SCHEMBL30296862 | 0.71 | HRH4 (0.70) | HRH4HRH3LMNAHTTSMN1; SMN2 | |
| SCHEMBL239723 | 0.71 | ALDH1A1 (0.39) | LMNAMAPTHTT | |
| SCHEMBL2797830 | 0.70 | HRH4 (0.68) | HRH4HRH3LMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654249-A1 | ANTHELMINTIC AND INSECTICIDE PYRIMIDINE DERIVATIVES | Pharmacia & Upjohn Company LLC (US) | 2006-05-10 | — | — | EP | claimed |
| WO-2005014573-A1 | ANTHELMINTIC AND INSECTICIDE PYRIMIDINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-02-17 | — | — | WO | claimed |
| US-20050032810-A1 | Novel anthelmintic and insecticidal compositions | PHARMACIA AND UPJOHN COMPANY | 2005-02-10 | — | — | US | claimed |
| EP-1654249-A1 | ANTHELMINTIC AND INSECTICIDE PYRIMIDINE DERIVATIVES | Pharmacia & Upjohn Company LLC (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005014573-A1 | ANTHELMINTIC AND INSECTICIDE PYRIMIDINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-02-17 | — | — | WO | disclosed |
| US-20050032810-A1 | Novel anthelmintic and insecticidal compositions | PHARMACIA AND UPJOHN COMPANY | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032810-A1 | Novel anthelmintic and insecticidal compositions | ACHE, DHX29, DHX35 | HRH4 172/4885HRH3 153/4885DHFR 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.