Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 15/20 | 0.50 |
| ▸ | DHFR | P00374 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5743990 | 0.92 | DHFR (0.53) | SMPD3HRH4DHFRHRH3 | |
| Hydrochloric Acid SCHEMBL5743802 | 0.90 | DHFR (0.52) | SMPD3HRH4DHFRHRH3 | |
| SCHEMBL5790892 | 0.86 | HRH4 (0.59) | SMPD3HRH4DHFRHRH3 | |
| SCHEMBL5742735 | 0.78 | MAPT (0.64) | HRH4DHFRHRH3 | |
| SCHEMBL5741204 | 0.78 | HRH4 (0.50) | HRH4DHFRHRH3 | |
| SCHEMBL606508 | 0.77 | HRH4 (0.60) | HRH4HRH3 | |
| SCHEMBL30834281 | 0.76 | IRAK4 (0.42) | SMPD3HRH4HRH3 | |
| SCHEMBL27201272 | 0.76 | IRAK4 (0.42) | SMPD3HRH4HRH3 | |
| SCHEMBL28690827 | 0.75 | NPC1 (0.53) | SMPD3DHFRHRH3PDE10A | |
| SCHEMBL5740772 | 0.75 | SMN1; SMN2 (0.53) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654249-A1 | ANTHELMINTIC AND INSECTICIDE PYRIMIDINE DERIVATIVES | Pharmacia & Upjohn Company LLC (US) | 2006-05-10 | — | — | EP | claimed |
| WO-2005014573-A1 | ANTHELMINTIC AND INSECTICIDE PYRIMIDINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-02-17 | — | — | WO | claimed |
| US-20050032810-A1 | Novel anthelmintic and insecticidal compositions | PHARMACIA AND UPJOHN COMPANY | 2005-02-10 | — | — | US | claimed |
| US-20050032810-A1 | Novel anthelmintic and insecticidal compositions | PHARMACIA AND UPJOHN COMPANY | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032810-A1 | Novel anthelmintic and insecticidal compositions | ACHE, DHX29, DHX35 | SMPD3 155/4885HRH4 172/4885DHFR 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.