SCHEMBL5741231

SCHEMBL5741231

CC(C)(C)OC(=O)N1CCC(CN2CCN(S(=O)(=O)c3ccc4cc(Cl)ccc4c3)CC2=O)(C(=O)O)CC1

nearest known ligand 0.44

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
F10 P00742 9/20 0.40
STS P08842 2/20 0.40
TGM2 P21980 3/20 0.39
F13A1 P00488 2/20 0.39
TGM1 P22735 2/20 0.39
TGM3 Q08188 1/20 0.39
MAPT P10636 1/20 0.38
GPR119 Q8TDV5 2/20 0.38
POLB P06746 1/20 0.38
F2 P00734 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5741347 0.94 STS (0.40) F10STSTGM2F13A1TGM1
SCHEMBL7054303 0.92 STS (0.41) F10STSTGM2F13A1TGM1
SCHEMBL7052836 0.89 STS (0.40) F10STSTGM2F13A1TGM1
SCHEMBL7115064 0.89 LMNA (0.39) F10STSTGM2F13A1TGM1
SCHEMBL7051249 0.87 STS (0.40) F10STSTGM2F13A1TGM1
SCHEMBL7115070 0.84 STS (0.38) F10STSTGM2F13A1TGM1
SCHEMBL5741924 0.84 MAPT (0.42) F10STSTGM2F13A1TGM1
SCHEMBL6895114 0.83 STS (0.46) F10STSMAPTGPR119
SCHEMBL5740739 0.83 P2RX7 (0.41) F10STSTGM2F13A1TGM1
SCHEMBL6887446 0.83 GPR119 (0.47) F10STSTGM2F13A1TGM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7109200-B2 Carbamate derivatives, process for producing the same and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2006-09-19 US disclosed
EP-1340753-B1 CARBAMATE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF TAKEDA PHARMACEUTICAL (JP) 2006-01-11 EP disclosed
US-20040038986-A1 Carbamate derivatives, process for producing the same and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2004-02-26 US disclosed
US-6680312-B2 FOR THERAPY OF CARDIAC INFARCTION, CEREBRAL THROMBOSIS; INHIBIT ACTIVATED COAGULATION FACTOR X (FXA) TO SHOW ANTI-COAGULANT ACTIVITY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2004-01-20 US disclosed
EP-1340753-A1 CARBAMATE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2003-09-03 EP disclosed
US-20020193382-A1 Sulfonamide derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY, LIMITED (JP) 2002-12-19 US disclosed
US-6403595-B1 ANTICOAGULANTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-06-11 US disclosed
EP-1054005-A1 SULFONAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND UTILIZATION THEREOF Takeda Chemical Industries, Ltd. (JP) 2000-11-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040038986-A1 Carbamate derivatives, process for producing the same and use thereof CFH, F11, F2 F10 4/4885STS 400/4885TGM2 1508/4885
US-20020193382-A1 Sulfonamide derivatives, their production and use F12, F11, F2 F10 5/4885STS 13/4885TGM2 2701/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.