Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.43 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4653136 | 0.77 | TDO2 (0.43) | MAPTTP53SMN1; SMN2DPP4ALDH1A1 | |
| SCHEMBL28603782 | 0.75 | MAOA (0.40) | MAPTTP53SMN1; SMN2DPP4ALDH1A1 | |
| SCHEMBL14027112 | 0.69 | RPS6KB2 (0.53) | MAPTRPS6KB2ERN1ALDH1A1GAA | |
| SCHEMBL5891734 | 0.68 | CHEK1 (0.43) | MAPTERN1ALDH1A1GAAMEN1 | |
| SCHEMBL3545 | 0.68 | L3MBTL1 (0.57) | MAPTTP53SMN1; SMN2RPS6KB2DPP4 | |
| SCHEMBL16291133 | 0.68 | L3MBTL1 (0.57) | MAPTTP53SMN1; SMN2RPS6KB2DPP4 | |
| SCHEMBL1531075 | 0.67 | KDM4E (0.38) | MAPTTP53SMN1; SMN2DPP4RXFP1 | |
| SCHEMBL6067827 | 0.67 | RPS6KB2 (0.47) | MAPTTP53SMN1; SMN2RPS6KB2ERN1 | |
| SCHEMBL6281078 | 0.67 | KDM4E (0.56) | MAPTTP53SMN1; SMN2SMPD3RXFP1 | |
| SCHEMBL2436787 | 0.66 | L3MBTL1 (0.50) | MAPTTP53SMN1; SMN2RPS6KB2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1072266-B8 | THIENYLAZOLYLALCOXYETHANAMINES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2006-10-18 | — | — | EP | disclosed |
| EP-1072266-B1 | THIENYLAZOLYLALCOXYETHANAMINES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2005-08-24 | — | — | EP | disclosed |
| CN-1189170-C | Thienylazolylalkoxyethylamines, their preparation and their use as medicaments | ESTEVE LABOR DR (ES) | 2005-02-16 | — | — | CN | disclosed |
| CN-1303283-A | Thienylazolylal coxyethanamines, their preparation and their application as medicaments | ESTEVE LABOR DR (ES) | 2001-07-11 | — | — | CN | disclosed |
| WO-1999052525-A1 | THIENYLAZOLYLALCOXYETHANAMINES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1999-10-21 | — | — | WO | disclosed |