Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.33 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | PER2 | O15055 | 1/20 | 0.31 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.31 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.31 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.31 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5743012 | 0.88 | PTPN1 (0.35) | KEAP1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5743320 | 0.87 | KEAP1 (0.35) | TAS2R14KEAP1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4267918 | 0.83 | PTPN1 (0.36) | SCD5PTPN1MTNR1AMTNR1BDUSP3 | |
| SCHEMBL4265268 | 0.80 | MMP2 (0.39) | PTPN1MTNR1AMTNR1BDUSP3 | |
| SCHEMBL4260729 | 0.78 | PTPN1 (0.35) | PTPN1MTNR1AMTNR1BDUSP3 | |
| SCHEMBL5740879 | 0.78 | PTPN2 (0.36) | KEAP1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4267881 | 0.77 | PTPN1 (0.34) | PTPN1MTNR1AMTNR1BDUSP3 | |
| SCHEMBL5743846 | 0.77 | TAS2R14 (0.36) | TAS2R14KEAP1DAGLAPTPN1MTNR1A | |
| SCHEMBL4275242 | 0.75 | MMP2 (0.40) | PTPN1MTNR1AMTNR1BDUSP3 | |
| SCHEMBL4261640 | 0.73 | PTPN1 (0.38) | PTPN1MTNR1AMTNR1BDUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006525365-A | — | — | 2006-11-09 | — | — | JP | claimed |
| EP-1620422-A2 | PHENYL SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-02-01 | — | — | EP | claimed |
| WO-2004099170-A2 | PHENYL SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-11-18 | — | — | WO | claimed |