Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
| ▸ | PTPN9 | P43378 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | DAGLA | Q9Y4D2 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5743320 | 0.90 | KEAP1 (0.35) | PTPN2PTPN1KEAP1PTPN6DUSP3 | |
| SCHEMBL5740586 | 0.88 | PTPN1 (0.36) | PTPN2PTPN1KEAP1PTPRCPTPN6 | |
| SCHEMBL5743849 | 0.78 | TAS2R14 (0.35) | PTPN2PTPN1KEAP1PTPN6DUSP3 | |
| SCHEMBL4264656 | 0.74 | PPARA (0.35) | PTPN2PTPN1PTPRCPTPN6PTPN9 | |
| SCHEMBL4459383 | 0.73 | KEAP1 (0.48) | KEAP1NPSR1DAGLACYP3A4CYP2C19 | |
| SCHEMBL5064407 | 0.70 | KEAP1 (0.40) | PTPN2PTPN1KEAP1NPSR1DAGLA | |
| SCHEMBL5767369 | 0.69 | MMP12 (0.36) | GAA | |
| SCHEMBL5743318 | 0.68 | KEAP1 (0.37) | KEAP1NPSR1DAGLAMEN1KMT2A | |
| SCHEMBL5740580 | 0.68 | PTPN1 (0.36) | PTPN2PTPN1KEAP1NPSR1DAGLA | |
| SCHEMBL5744684 | 0.67 | ALOX5 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006525365-A | — | — | 2006-11-09 | — | — | JP | claimed |
| EP-1620422-A2 | PHENYL SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-02-01 | — | — | EP | claimed |
| WO-2004099170-A2 | PHENYL SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-11-18 | — | — | WO | claimed |