Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5396416 | 0.87 | ALDH1A1 (0.41) | L3MBTL1NPC1SMN1; SMN2MEN1MAPT | |
| SCHEMBL5782533 | 0.83 | ALDH1A1 (0.40) | L3MBTL1SMN1; SMN2 | |
| SCHEMBL3944692 | 0.82 | L3MBTL1 (0.40) | L3MBTL1NPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL1382277 | 0.79 | ALDH1A1 (0.42) | L3MBTL1NPC1SMN1; SMN2ATMMAPT | |
| SCHEMBL1572762 | 0.73 | SRD5A2 (0.39) | NPC1RAB9ASMN1; SMN2LNPEPMAOB | |
| SCHEMBL4509609 | 0.71 | LNPEP (0.42) | HPGDLNPEPMAOBPARP10SRD5A2 | |
| SCHEMBL7291737 | 0.71 | MAOB (0.58) | L3MBTL1RAB9ASMN1; SMN2HDAC6MAOB | |
| SCHEMBL5407521 | 0.71 | ALDH1A1 (0.38) | L3MBTL1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL146411 | 0.70 | RXRA (0.46) | NPC1HPGDRAB9ASMN1; SMN2ATM | |
| SCHEMBL9047043 | 0.69 | SRD5A2 (0.65) | L3MBTL1NPC1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664047-A1 | SUBSTITUTED INDOLIZINE 1,2,3,6,7,8 DERIVATIVES, FGFS INHIBITORS, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | Sanofi-Aventis (FR) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005028476-A1 | SUBSTITUTED INDOLIZINE 1,2,3,6,7,8 DERIVATIVES, FGFS INHIBITORS, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI-AVENTIS (FR) | 2005-03-31 | — | — | WO | disclosed |