Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2893297 | 0.91 | ALDH1A1 (0.35) | ALDH1A1LMNAPOLBKDM4ENOTUM | |
| SCHEMBL2895448 | 0.88 | GRM5 (0.45) | GRM5PKMALDH1A1LMNAPOLB | |
| SCHEMBL2895031 | 0.76 | RXRA (0.39) | ALDH1A1LMNAKDM4EMAPTNPC1 | |
| SCHEMBL3107652 | 0.76 | PKM (0.46) | GRM5PKMALDH1A1LMNAPOLB | |
| SCHEMBL2889986 | 0.74 | NFE2L2 (0.37) | GRM5ALDH1A1LMNAPOLBKDM4E | |
| SCHEMBL2893751 | 0.73 | FAAH (0.40) | GRM5 | |
| SCHEMBL2896761 | 0.73 | GRM5 (0.44) | GRM5ALDH1A1LMNAPOLBMAPT | |
| SCHEMBL5750726 | 0.72 | PKM (0.37) | GRM5PKMALDH1A1LMNAMAPT | |
| SCHEMBL31568334 | 0.71 | ABCG2 (0.46) | GRM5PKMALDH1A1LMNAPOLB | |
| SCHEMBL2889795 | 0.71 | GRM5 (0.46) | GRM5PKMALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716125-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080356-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |