Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 8/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 5/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065078 | 0.90 | SIRT2 (0.47) | CHRM4SIRT2SIRT1SIRT3ENPP1 | |
| SCHEMBL4066842 | 0.83 | ENPP1 (0.46) | CHRM4SIRT2SIRT1SIRT3ENPP1 | |
| SCHEMBL20771438 | 0.80 | NCF1 (0.54) | SIRT2SIRT1SIRT3ENPP1ACHE | |
| SCHEMBL1729130 | 0.78 | ENPP1 (0.51) | CHRM4SIRT2SIRT1SIRT3ENPP1 | |
| SCHEMBL4064002 | 0.77 | KCNH2 (0.49) | — | |
| SCHEMBL1728435 | 0.77 | SIRT2 (0.50) | CHRM4SIRT2SIRT1SIRT3ENPP1 | |
| SCHEMBL4071027 | 0.76 | HTR1A (0.46) | ALDH1A1 | |
| SCHEMBL4065882 | 0.76 | NCF1 (0.52) | SIRT2SIRT1SIRT3ENPP1KMT2A | |
| SCHEMBL1729014 | 0.75 | DRD2 (0.52) | CHRM4SIRT2SIRT1SIRT3 | |
| SCHEMBL4073225 | 0.74 | SUV39H2 (0.47) | CHRM4SIRT2SIRT1SIRT3ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605938-A4 | ANTIBACTERIAL AGENTS | GLAXO GROUP LTD (GB) | 2006-11-22 | — | — | EP | disclosed |
| EP-1605938-A2 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004087145-A2 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2004-10-14 | — | — | WO | disclosed |