Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 5/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 2/20 | 0.39 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764609 | 0.77 | KDM4E (0.43) | MPOKDM4CNPC1RAB9AKDM4E | |
| SCHEMBL4360026 | 0.74 | ALDH1A1 (0.41) | MPOKDM4CKDM4EERN1LMNA | |
| SCHEMBL1149953 | 0.74 | MPO (0.36) | MPOESR2NPC1RAB9AKDM4E | |
| SCHEMBL25273272 | 0.74 | ERN1 (0.38) | KDM4EERN1LMNA | |
| SCHEMBL1092954 | 0.72 | MPO (0.56) | MPOESR2NPC1RAB9AKDM4E | |
| SCHEMBL28792817 | 0.72 | ESR2 (0.74) | MPOESR2NPC1RAB9AKDM4E | |
| SCHEMBL28792826 | 0.72 | MPO (0.56) | MPOESR2NPC1RAB9AKDM4E | |
| SCHEMBL18294577 | 0.72 | MPO (0.61) | MPOESR2KDM4CKDM4EHPGD | |
| SCHEMBL14116547 | 0.72 | MPO (0.56) | MPOESR2NPC1RAB9AKDM4E | |
| SCHEMBL6411455 | 0.71 | CHEK1 (0.68) | MPOESR2CHEK1AURKACSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110655521-A | 12H-indazole [2,1-a ] cinnoline-12-ketone compound and application thereof | 浙江工业大学 | 2020-01-07 | — | — | CN | claimed |
| CN-110742892-B | Application of 12H-indazole [2,1-a ] cinnoline-12-ketone compound | 浙江工业大学 | 2022-05-24 | — | — | CN | disclosed |
| CN-110655521-B | 12H-indazole [2,1-a ] cinnoline-12-ketone compound and application thereof | 浙江工业大学 | 2020-10-27 | — | — | CN | disclosed |
| CN-110742892-A | Application of 12H-indazole [2,1-a ] cinnoline-12-ketone compound | 浙江工业大学 | 2020-02-04 | — | — | CN | disclosed |
| CN-110655521-A | 12H-indazole [2,1-a ] cinnoline-12-ketone compound and application thereof | 浙江工业大学 | 2020-01-07 | — | — | CN | disclosed |
| EP-1651602-A2 | ARYL HETEROAROMATIC PRODUCTS, COMPOSITIONS COMPRISING THE SAME AND USE THEREOF | Aventis Pharma S.A. (FR) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005009947-A2 | ARYL HETEROAROMATIC PRODUCTS, COMPOSITIONS COMPRISING THE SAME AND USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2005-02-03 | — | — | WO | disclosed |